Literature DB >> 19299110

Safety of an IV formulation of carbamazepine.

Jeannine M Conway1, James R White, Angela K Birnbaum, R Eugene Ramsay, Page B Pennell, John O Rarick, Luna Musib, Ilo E Leppik, James C Cloyd.   

Abstract

An intravenous formulation of carbamazepine (CBZ) was administered to 113 (60 male; 53 female) persons with epilepsy aged 19-87 years. Subjects received 100mg of study drug as replacement for 100mg of their usual morning dose of CBZ. There were no significant changes in blood pressure or heart rate suggesting that this formulation can be developed as replacement therapy for persons unable to take oral CBZ.

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Year:  2009        PMID： 19299110      PMCID： PMC3973440          DOI： 10.1016/j.eplepsyres.2009.01.013

Source DB:  PubMed          Journal:  Epilepsy Res        ISSN： 0920-1211            Impact factor:   3.045


  3 in total

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Authors:  D Slain; P D Rogers; J D Cleary; S W Chapman
Journal:  Ann Pharmacother       Date:  2001-06       Impact factor: 3.154

2.  Factors affecting antiepileptic drug pharmacokinetics in community-dwelling elderly.

Authors:  James C Cloyd; Susan Marino; Angela K Birnbaum
Journal:  Int Rev Neurobiol       Date:  2007       Impact factor: 3.230

Review 3.  Cyclodextrins.

Authors:  Valentino J Stella; Quanren He
Journal:  Toxicol Pathol       Date:  2008-01       Impact factor: 1.902
  3 in total
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1.  Safety of an intravenous formulation of lamotrigine.

Authors:  Jeannine M Conway; Angela K Birnbaum; Ilo E Leppik; Page B Pennell; James R White; John O Rarick; Rory P Remmel
Journal:  Seizure       Date:  2014-01-31       Impact factor: 3.184

2.  Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy.

Authors:  Ghada F Ahmed; Richard C Brundage; Susan E Marino; James C Cloyd; Ilo E Leppik; Page B Pennell; R Eugene Ramsay; Angela K Birnbaum
Journal:  J Clin Pharmacol       Date:  2013-02-13       Impact factor: 3.126

Review 3.  Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

Authors:  Sima I Patel; Angela K Birnbaum; James C Cloyd; Ilo E Leppik
Journal:  CNS Drugs       Date:  2015-12       Impact factor: 5.749

4.  Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex.

Authors:  S E Marino; A K Birnbaum; I E Leppik; J M Conway; L C Musib; R C Brundage; R E Ramsay; P B Pennell; J R White; C R Gross; J O Rarick; U Mishra; J C Cloyd
Journal:  Clin Pharmacol Ther       Date:  2012-01-25       Impact factor: 6.875

5.  Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy.

Authors:  Dwain Tolbert; James Cloyd; Victor Biton; Ihor Bekersky; Mark Walzer; David Wesche; Rebecca Drummond; Deborah Lee
Journal:  Epilepsia       Date:  2015-05-16       Impact factor: 5.864
  5 in total

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