Literature DB >> 19298984

Antimalarial sesquiterpene lactones from Distephanus angulifolius.

Martin M Pedersen1, Jude C Chukwujekwu, Carmen A Lategan, Johannes van Staden, Peter J Smith, Dan Staerk.   

Abstract

Combined use of bioassay-guided fractionation based on in vitro antiplasmodial assay and dereplication based on HPLC-PDA-MS-SPE-NMR led to isolation of (6S,7R,8S)-14-acetoxy-8-[2-hydroxymethylacrylat]-15-helianga-1(10),4,11(13)-trien-15-al-6,12-olid and (5R,6R,7R,8S,10S)-14-acetoxy-8-[2-hydroxymethylacrylat]-elema-1,3,11(13)-trien-15-al-6,12-olid, along with vernodalol, vernodalin, and 11,13beta-dihydroxyvernodalin from extract of Distephanus angulifolius. All compounds were identified by spectroscopic methods, including 1D and 2D homo- and heteronuclear NMR experiments. The isolated compounds showed IC(50) values in the range 1.6-3.8 microM and 2.1-4.9 microM against chloroquine sensitive D10 and chloroquine resistant W2 Plasmodium falciparum strains, respectively.

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Year:  2009        PMID： 19298984     DOI： 10.1016/j.phytochem.2009.02.005

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  14 in total

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Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

5.  Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds.

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Journal:  Malar J       Date:  2015-07-25       Impact factor: 2.979

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7.  Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds.

Authors:  Chung Yeng Looi; Aditya Arya; Foo Kit Cheah; Bushra Muharram; Kok Hoong Leong; Khalit Mohamad; Won Fen Wong; Nitika Rai; Mohd Rais Mustafa
Journal:  PLoS One       Date:  2013-02-20       Impact factor: 3.240

Review 8.  The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.

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Journal:  Malar J       Date:  2013-12-13       Impact factor: 2.979

Review 9.  Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India.

Authors:  Sujogya Kumar Panda; Walter Luyten
Journal:  Parasite       Date:  2018-03-12       Impact factor: 3.000

10.  Characterization of Antileishmanial Compounds from Lawsonia inermis L. Leaves Using Semi-High Resolution Antileishmanial Profiling Combined with HPLC-HRMS-SPE-NMR.

Authors:  Kashif Iqbal; Javeid Iqbal; Dan Staerk; Kenneth T Kongstad
Journal:  Front Pharmacol       Date:  2017-05-31       Impact factor: 5.810
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