| Literature DB >> 19297235 |
Teresa Lorenzi1, Rosaria Meli, Daniela Marzioni, Manrico Morroni, Alessandra Baragli, Mario Castellucci, Oreste Gualillo, Giampiero Muccioli.
Abstract
Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach's oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis.Entities:
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Year: 2009 PMID： 19297235 DOI： 10.1016/j.cytogfr.2009.02.003
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638