| Literature DB >> 19297155 |
Baohe Tian1, Meizi He, Shixing Tang, Indira Hewlett, Zhiwu Tan, Jiebo Li, Yinxue Jin, Ming Yang.
Abstract
HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC(50) values of 0.21 and 0.17 microM respectively.Entities:
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Year: 2009 PMID： 19297155 DOI： 10.1016/j.bmcl.2009.02.116
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823