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Literature DB >> 19296557

Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide.

Yu Hoshino¹, Takeo Urakami, Takashi Kodama, Hiroyuki Koide, Naoto Oku, Yoshio Okahata, Kenneth J Shea.

Abstract

Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.

Entities: CellLine Chemical Disease Gene Species

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Year: 2009 PMID： 19296557 PMCID： PMC2804256 DOI： 10.1002/smll.200900186

Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281

11 in total

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24 in total

1. The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo.

Authors: Yu Hoshino; Hiroyuki Koide; Keiichi Furuya; Walter W Haberaecker; Shih-Hui Lee; Takashi Kodama; Hiroaki Kanazawa; Naoto Oku; Kenneth J Shea
Journal: Proc Natl Acad Sci U S A Date: 2011-12-22 Impact factor: 11.205

2. Temperature-responsive "catch and release" of proteins by using multifunctional polymer-based nanoparticles.

Authors: Keiichi Yoshimatsu; Benjamin K Lesel; Yusuke Yonamine; John M Beierle; Yu Hoshino; Kenneth J Shea
Journal: Angew Chem Int Ed Engl Date: 2012-01-27 Impact factor: 15.336

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Journal: Biomacromolecules Date: 2012-08-14 Impact factor: 6.988

4. Selective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticles.

Authors: Sergiy Korposh; Iva Chianella; Antonio Guerreiro; Sarah Caygill; Sergey Piletsky; Stephen W James; Ralph P Tatam
Journal: Analyst Date: 2014-05-07 Impact factor: 4.616

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Authors: Jiarong Zhou; Ashley V Kroll; Maya Holay; Ronnie H Fang; Liangfang Zhang
Journal: Adv Mater Date: 2019-06-17 Impact factor: 30.849

6. Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: a plastic antibody.

Authors: Yu Hoshino; Hiroyuki Koide; Takeo Urakami; Hiroaki Kanazawa; Takashi Kodama; Naoto Oku; Kenneth J Shea
Journal: J Am Chem Soc Date: 2010-05-19 Impact factor: 15.419

7. Challenges and opportunities in developing nanoparticles for detoxification.

Authors: Xin Qu; Maling Gou; Jana Zaidan; Kang Zhang; Shaochen Chen
Journal: Nanomedicine (Lond) Date: 2014-11 Impact factor: 5.307

8. Preparation and Characterization of Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic Peptide (ANP).

Authors: Chunyan Wang; Mark Howell; Payal Raulji; Yvonne Davis; Subhra Mohapatra
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9. Protein imprinting in polyacrylamide-based gels.

Authors: Maya Zayats; Andrew J Brenner; Peter C Searson
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10. Engineered synthetic polymer nanoparticles as IgG affinity ligands.

Authors: Shih-Hui Lee; Yu Hoshino; Arlo Randall; Zhiyang Zeng; Piere Baldi; Ruey-An Doong; Kenneth J Shea
Journal: J Am Chem Soc Date: 2012-09-17 Impact factor: 15.419