PURPOSE: A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells. METHODS: The methods used for the meta-analysis were recommended in several standard text books. Three specific variables related to ELF-EMF exposure characteristics were examined in the meta-analysis: (i) frequency (Hz), (ii) flux density (mT), and (iii) in occupationally exposed individuals. RESULT AND CONCLUSIONS: (1) The difference between ELF-EMF-exposed and control cells as well as the 'effect size' due to ELF-EMF exposure were biologically small (although statistically significant) with very few exceptions. (2) At certain ELF-EMF exposure conditions there was a statistically significant increase in genetic damage assessed from some end-points. (3) The mean indices for chromosomal aberrations and micronuclei end-points in ELF-EMF-exposed and control cells were within the spontaneous levels reported in historical database. (4) Considerable evidence for publication bias was found in the meta-analysis.
PURPOSE: A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells. METHODS: The methods used for the meta-analysis were recommended in several standard text books. Three specific variables related to ELF-EMF exposure characteristics were examined in the meta-analysis: (i) frequency (Hz), (ii) flux density (mT), and (iii) in occupationally exposed individuals. RESULT AND CONCLUSIONS: (1) The difference between ELF-EMF-exposed and control cells as well as the 'effect size' due to ELF-EMF exposure were biologically small (although statistically significant) with very few exceptions. (2) At certain ELF-EMF exposure conditions there was a statistically significant increase in genetic damage assessed from some end-points. (3) The mean indices for chromosomal aberrations and micronuclei end-points in ELF-EMF-exposed and control cells were within the spontaneous levels reported in historical database. (4) Considerable evidence for publication bias was found in the meta-analysis.
Authors: Carly A Buckner; Alison L Buckner; Stan A Koren; Michael A Persinger; Robert M Lafrenie Journal: PLoS One Date: 2015-04-14 Impact factor: 3.240
Authors: Arnold Kuzniar; Charlie Laffeber; Berina Eppink; Karel Bezstarosti; Dick Dekkers; Henri Woelders; A Peter M Zwamborn; Jeroen Demmers; Joyce H G Lebbink; Roland Kanaar Journal: PLoS One Date: 2017-02-24 Impact factor: 3.240
Authors: Melissa Manser; Mohamad R Abdul Sater; Christoph D Schmid; Faiza Noreen; Manuel Murbach; Niels Kuster; David Schuermann; Primo Schär Journal: Sci Rep Date: 2017-03-07 Impact factor: 4.379