Literature DB >> 1929544

Stimulation of anti-RNP antibody binding to cultured keratinocytes by estradiol.

F Furukawa1, S Imamura, D A Norris.   

Abstract

Antibodies to extractable nuclear antigens (ENA) are frequently demonstrated in the serum of patients with cutaneous lupus erythematosus. To gain a better understanding of the influence of sex hormones on cutaneous lupus, we investigated the in vitro binding of anti-ENA antibodies to cultured human keratinocytes. Estradiol-beta augmented the binding of anti-RNP, anti-SS-A/Ro, and anti-SS-B/La antibodies to cultured cells, but produced no enhancement of the binding of anti-Sm antibodies. In addition, we examined the effects of 16-alpha-hydroxyestrone, a highly estrogenic metabolite, on the binding of anti-ENA antibodies to cultured cells. This agent did not produce any augmentation of binding. Based on these experiments, we discuss the influence of estradiol on cutaneous lupus.

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Year:  1991        PMID： 1929544     DOI： 10.1007/bf01106112

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  17 in total

1.  Binding of antibodies to nonhistone nucleoproteins on keratinocytes in suspensions.

Authors:  P J Velthuis; E G Wildschut; H Baart de la Faille; W A van Vloten; H van Weelden; L Kater
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

2.  Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy.

Authors:  F Furukawa; M Kashihara; S Imamura; G Ohshio; Y Hamashima
Journal:  Arch Dermatol Res       Date:  1986       Impact factor: 3.017

3.  Sex steroids and the rheumatic diseases.

Authors:  R G Lahita
Journal:  Arthritis Rheum       Date:  1985-02

4.  Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset.

Authors:  R D Sontheimer; J R Thomas; J N Gilliam
Journal:  Arch Dermatol       Date:  1979-12

5.  Antinuclear and anticytoplasmic antibodies in lupus erythematosus.

Authors:  K B Kulick; M Reichlin
Journal:  Clin Dermatol       Date:  1985 Jul-Sep       Impact factor: 3.541

6.  Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus.

Authors:  F Furukawa; M Kashihara-Sawami; M B Lyons; D A Norris
Journal:  J Invest Dermatol       Date:  1990-01       Impact factor: 8.551

7.  Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus.

Authors:  M R Lerner; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

8.  Serologic and HLA associations in subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus.

Authors:  R D Sontheimer; P J Maddison; M Reichlin; R E Jordon; P Stastny; J N Gilliam
Journal:  Ann Intern Med       Date:  1982-11       Impact factor: 25.391

9.  Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/Ro and SS-B/La. Another possible mechanism for estradiol influence of lupus erythematosus.

Authors:  F Furukawa; M B Lyons; L A Lee; S N Coulter; D A Norris
Journal:  J Immunol       Date:  1988-09-01       Impact factor: 5.422

10.  Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture.

Authors:  S T Boyce; R G Ham
Journal:  J Invest Dermatol       Date:  1983-07       Impact factor: 8.551
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  3 in total

Review 1.  The role of autoantigens in the induction and maintenance of autoimmunity.

Authors:  P H Plotz
Journal:  Mol Biol Rep       Date:  1992-06       Impact factor: 2.316

2.  Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.

Authors:  Ryan Webb; Jennifer A Kelly; Emily C Somers; Travis Hughes; Kenneth M Kaufman; Elena Sanchez; Swapan K Nath; Gail Bruner; Marta E Alarcón-Riquelme; Gary S Gilkeson; Diane L Kamen; Bruce C Richardson; John B Harley; Amr H Sawalha
Journal:  Ann Rheum Dis       Date:  2010-09-29       Impact factor: 19.103

3.  Adenovirus infection induces loss of HLA class I and CD3 antigens, but does not induce cell surface presentation of the La (SS-B) autoantigen.

Authors:  R Peek; J R Westphal; G J Pruijn; A J Van der Kemp; W J Van Venrooij
Journal:  Clin Exp Immunol       Date:  1994-06       Impact factor: 4.330
  3 in total

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