BACKGROUND: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. METHODS: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442). RESULTS: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV(1) % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores. CONCLUSIONS: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity. Copyright (C) 2009 S. Karger AG, Basel.
BACKGROUND: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. METHODS: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442). RESULTS: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV(1) % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores. CONCLUSIONS: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity. Copyright (C) 2009 S. Karger AG, Basel.
Authors: Erik Melén; Alvin T Kho; Sunita Sharma; Roger Gaedigk; J Steven Leeder; Thomas J Mariani; Vincent J Carey; Scott T Weiss; Kelan G Tantisira Journal: Respir Res Date: 2011-06-23
Authors: Elham Rostami; Frank Krueger; Serguei Zoubak; Olga Dal Monte; Vanessa Raymont; Matteo Pardini; Colin A Hodgkinson; David Goldman; Mårten Risling; Jordan Grafman Journal: PLoS One Date: 2011-11-08 Impact factor: 3.240
Authors: Aleksandra Szczepankiewicz; Anna Bręborowicz; Paulina Sobkowiak; Anna Popiel Journal: World Allergy Organ J Date: 2010-09 Impact factor: 4.084