BACKGROUND: The negative prognostic role of pathologic fracture in osteosarcoma is not determined, as previous case-control and retrospective cohort studies have produced contradictory results. METHODS: We conducted both cohort (n = 384) and case-control (n = 111) studies on 37 pathologically fractured localized osteosarcoma of extremity. RESULTS: In cohort study, patients with a fracture showed a tendency of poorer survival, but the difference did not reach the level of significance (5-year metastasis-free survival rates; 48% for cases vs. 61% for controls; P = 0.06). A case-control study on 37 fractured and 74 control recruited from 347 patients matched for tumor size and location showed no survival difference between the cases and controls (P = 0.12). CONCLUSIONS: Reported negative prognostic effect of a pathologic fracture is likely to be due to confounding by tumor size and location. The present study suggests that the presence of a pathologic fracture has no prognostic relevance.
BACKGROUND: The negative prognostic role of pathologic fracture in osteosarcoma is not determined, as previous case-control and retrospective cohort studies have produced contradictory results. METHODS: We conducted both cohort (n = 384) and case-control (n = 111) studies on 37 pathologically fracturedlocalized osteosarcoma of extremity. RESULTS: In cohort study, patients with a fracture showed a tendency of poorer survival, but the difference did not reach the level of significance (5-year metastasis-free survival rates; 48% for cases vs. 61% for controls; P = 0.06). A case-control study on 37 fractured and 74 control recruited from 347 patients matched for tumor size and location showed no survival difference between the cases and controls (P = 0.12). CONCLUSIONS: Reported negative prognostic effect of a pathologic fracture is likely to be due to confounding by tumor size and location. The present study suggests that the presence of a pathologic fracture has no prognostic relevance.
Authors: Julio J Jauregui; Vidushan Nadarajah; Joseph Munn; Robert Pivec; Bhaveen H Kapadia; Daniel M Lerman; Aditya V Maheshwari Journal: Indian J Surg Oncol Date: 2018-01-20
Authors: Lindsay Haynes; Sue C Kaste; Kirsten K Ness; Jianrong Wu; Lucia Ortega-Laureano; Michael Bishop; Michael Neel; Bhaskar Rao; Israel Fernandez-Pineda Journal: Pediatr Blood Cancer Date: 2016-11-05 Impact factor: 3.167
Authors: Philipp T Funovics; Gundula Edelhauser; Martin A Funovics; Christoph Laux; Dominik Berzaczy; Bernd Kubista; Rainer I Kotz; Martin Dominkus Journal: Int Orthop Date: 2011-01-21 Impact factor: 3.075
Authors: Santiago A Lozano Calderón; Cassandra Garbutt; Jason Kim; Christopher E Lietz; Yen-Lin Chen; Karen Bernstein; Ivan Chebib; G Petur Nielsen; Vikram Deshpande; Renee Rubio; Yaoyu E Wang; John Quackenbush; Thomas Delaney; Kevin Raskin; Joseph Schwab; Gregory Cote; Dimitrios Spentzos Journal: Clin Orthop Relat Res Date: 2019-09 Impact factor: 4.176