Literature DB >> 1929338

Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release.

R Urbaschek1, D N Männel, R Urbanczik.   

Abstract

Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release determined in human monocytes in vitro. Therefore, it is concluded that the protective effect of INH against lethal endotoxin is not due to a suppressive effect of INH on TNF production.

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Year:  1991        PMID： 1929338      PMCID： PMC245238          DOI： 10.1128/AAC.35.8.1666

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  The mediation of endotoxin-induced beneficial effects by cytokines.

Authors:  R Urbaschek; B Urbaschek
Journal:  Adv Exp Med Biol       Date:  1990       Impact factor: 2.622

2.  Optimal induction of tumor necrosis factor production in human monocytes requires complete S-form lipopolysaccharide.

Authors:  D N Männel; W Falk
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

Review 3.  The potential clinical significance of the isoniazid acetylator phenotype in the treatment of pulmonary tuberculosis.

Authors:  G A Ellard
Journal:  Tubercle       Date:  1984-09

4.  The sterilizing value of rifampicin and pyrazinamide in experimental short-course chemotherapy.

Authors:  J Grosset
Journal:  Bull Int Union Tuberc       Date:  1978-03

5.  Modulation of endotoxin lethality in mice by hydrazine sulfate.

Authors:  R Silverstein; C A Christoffersen; D C Morrison
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

6.  Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia.

Authors:  K J Tracey; Y Fong; D G Hesse; K R Manogue; A T Lee; G C Kuo; S F Lowry; A Cerami
Journal:  Nature       Date:  1987 Dec 17-23       Impact factor: 49.962

7.  Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.

Authors:  B Beutler; I W Milsark; A C Cerami
Journal:  Science       Date:  1985-08-30       Impact factor: 47.728

8.  Tumor necrosis factor induced stimulation of granulopoiesis and radioprotection.

Authors:  R Urbaschek; D N Männel; B Urbaschek
Journal:  Lymphokine Res       Date:  1987

9.  Oxidation of hydrazine metabolites formed from isoniazid.

Authors:  B H Lauterburg; C V Smith; E L Todd; J R Mitchell
Journal:  Clin Pharmacol Ther       Date:  1985-11       Impact factor: 6.875

10.  Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity.

Authors:  D L Fraker; M C Stovroff; M J Merino; J A Norton
Journal:  J Exp Med       Date:  1988-07-01       Impact factor: 14.307
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  2 in total

1.  rIL-22 as an adjuvant enhances the immunogenicity of rGroEL in mice and its protective efficacy against S. Typhi and S. Typhimurium.

Authors:  Gurpreet Kaur; Chitradevi STS; Charu Nimker; Anju Bansal
Journal:  Cell Mol Immunol       Date:  2014-05-26       Impact factor: 11.530

2.  Effect of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial.

Authors:  Heather J Zar; Mark F Cotton; Stanzi Strauss; Janine Karpakis; Gregory Hussey; H Simon Schaaf; Helena Rabie; Carl J Lombard
Journal:  BMJ       Date:  2006-11-03
  2 in total

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