OBJECTIVES: The objectives of the study was to examine which parental, fetal, and postnatal characteristics are associated with fat and lean mass at the age of 6 months and examine the effect of growth (catch-down, catch-up) in fetal life and early infancy on fat and lean mass. DESIGN: This study was embedded in the Generation R Study, a prospective cohort study from early fetal life onward. Body composition was measured by dual-energy X-ray absorptiometry in 252 infants at 6 months. Parental, fetal, and postnatal data were collected by physical and fetal ultrasound examinations and questionnaires. RESULTS: Children with fetal catch-up in weight (gain in weight sd score >0.67) in the second trimester tended to have a higher fat mass percentage [FM(%)] at 6 months of age, whereas children with fetal catch-down in weight had a lower FM(%) compared with nonchangers. In the third trimester, both catch-up and catch-down in weight were associated with an increase in FM(%) at 6 months. Children with catch-down in the third trimester had a greater risk for postnatal catch-up in weight greater than 0.67 sd score. Birth weight and weight at 6 wk were positively associated with fat mass at 6 months. Postnatal catch-up in weight within 6 wk after birth had the highest association with total and truncal FM(%) at 6 months. Total and truncal FM were higher in girls. CONCLUSION: Catch-down in weight in the third trimester was strongly associated with postnatal catch-up within 6 wk after birth, and both were associated with an increase in fat mass at the age of 6 months. Our study shows that fetal as well as postnatal growth patterns are associated with body composition in early childhood.
OBJECTIVES: The objectives of the study was to examine which parental, fetal, and postnatal characteristics are associated with fat and lean mass at the age of 6 months and examine the effect of growth (catch-down, catch-up) in fetal life and early infancy on fat and lean mass. DESIGN: This study was embedded in the Generation R Study, a prospective cohort study from early fetal life onward. Body composition was measured by dual-energy X-ray absorptiometry in 252 infants at 6 months. Parental, fetal, and postnatal data were collected by physical and fetal ultrasound examinations and questionnaires. RESULTS:Children with fetal catch-up in weight (gain in weight sd score >0.67) in the second trimester tended to have a higher fat mass percentage [FM(%)] at 6 months of age, whereas children with fetal catch-down in weight had a lower FM(%) compared with nonchangers. In the third trimester, both catch-up and catch-down in weight were associated with an increase in FM(%) at 6 months. Children with catch-down in the third trimester had a greater risk for postnatal catch-up in weight greater than 0.67 sd score. Birth weight and weight at 6 wk were positively associated with fat mass at 6 months. Postnatal catch-up in weight within 6 wk after birth had the highest association with total and truncal FM(%) at 6 months. Total and truncal FM were higher in girls. CONCLUSION: Catch-down in weight in the third trimester was strongly associated with postnatal catch-up within 6 wk after birth, and both were associated with an increase in fat mass at the age of 6 months. Our study shows that fetal as well as postnatal growth patterns are associated with body composition in early childhood.
Authors: Maria Aurora Chrestani; Iná S Santos; Bernardo L Horta; Samuel C Dumith; Maria Alice Souza de Oliveira Dode Journal: Matern Child Health J Date: 2013-04
Authors: D O Mook-Kanamori; L Ay; A Hofman; C M van Duijn; H A Moll; H Raat; A C S Hokken-Koelega; V W V Jaddoe Journal: J Endocrinol Invest Date: 2010-05-28 Impact factor: 4.256
Authors: Katie Larson Ode; Heather L Gray; Sara E Ramel; Michael K Georgieff; Ellen W Demerath Journal: J Pediatr Date: 2012-07-20 Impact factor: 4.406
Authors: B Durmuş; D H M Heppe; H R Taal; R Manniesing; H Raat; A Hofman; E A P Steegers; R Gaillard; V W V Jaddoe Journal: Int J Obes (Lond) Date: 2014-01-22 Impact factor: 5.095
Authors: Kirsten S de Fluiter; Inge A L P van Beijsterveldt; Wesley J Goedegebuure; Laura M Breij; Alexander M J Spaans; Dennis Acton; Anita C S Hokken-Koelega Journal: Eur J Clin Nutr Date: 2020-02-13 Impact factor: 4.016
Authors: Katherine A Bell; Carol L Wagner; Henry A Feldman; Roman J Shypailo; Mandy B Belfort Journal: Am J Clin Nutr Date: 2017-06-28 Impact factor: 7.045
Authors: Katherine A Sauder; Jill L Kaar; Anne P Starling; Brandy M Ringham; Deborah H Glueck; Dana Dabelea Journal: J Pediatr Date: 2017-02-01 Impact factor: 4.406