Literature DB >> 1929313

Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method.

P Casaccia1, A Ladogana, Y G Xi, L Ingrosso, M Pocchiari, M C Silvestrini, A Cittadini.   

Abstract

A simple, sensitive, and reproducible assay for the measurement of the amphotericin B concentration in tissue extracts was developed by using the fourth derivative of the absorption spectrum of amphotericin B between wavelengths of 330 and 430 nm. The amphotericin B concentration in spleen and brain was proportional to the total amount administered. The amphotericin B concentration in the brain was highly correlated with the increase in the mean incubation period of intracerebrally scrapie-infected hamsters.

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Year:  1991        PMID： 1929313      PMCID： PMC245196          DOI： 10.1128/AAC.35.7.1486

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Evidence that the transmission of one source of scrapie agent to hamsters involves separation of agent strains from a mixture.

Authors:  R H Kimberlin; C A Walker
Journal:  J Gen Virol       Date:  1978-06       Impact factor: 3.891

Review 2.  Antifungal agents useful in therapy of systemic fungal infections.

Authors:  G Medoff; J Brajtburg; G S Kobayashi; J Bolard
Journal:  Annu Rev Pharmacol Toxicol       Date:  1983       Impact factor: 13.820

3.  Distribution of doubly radiolabelled amphotericin B methyl ester and amphotericin B in the non-human primate, Macaca mulatta.

Authors:  R M Lawrence; P D Hoeprich; F A Jagdis; N Monji; A C Huston; C P Schaffner
Journal:  J Antimicrob Chemother       Date:  1980-03       Impact factor: 5.790

4.  Treatment and prophylaxis of disseminated infection due to Candida albicans in mice with liposome-encapsulated amphotericin B.

Authors:  G Lopez-Berestein; R Mehta; R L Hopfer; K Mills; L Kasi; K Mehta; V Fainstein; M Luna; E M Hersh; R Juliano
Journal:  J Infect Dis       Date:  1983-05       Impact factor: 5.226

5.  An internally-standardized assay for amphotericin B in tissues and plasma.

Authors:  J W Mayhew; C Fiore; T Murray; M Barza
Journal:  J Chromatogr       Date:  1983-05-13

6.  Combination of oral flucytosine and ketoconazole as therapy for experimental cryptococcal meningitis.

Authors:  P C Craven; J R Graybill
Journal:  J Infect Dis       Date:  1984-04       Impact factor: 5.226

7.  Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment.

Authors:  A Zuger; E Louie; R S Holzman; M S Simberkoff; J J Rahal
Journal:  Ann Intern Med       Date:  1986-02       Impact factor: 25.391

8.  Sensitive high-pressure liquid chromatographic assay for amphotericin B which incorporates an internal standard.

Authors:  G G Granich; G S Kobayashi; D J Krogstad
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

9.  Scrapie: how much do we really understand?

Authors:  R H Kimberlin
Journal:  Neuropathol Appl Neurobiol       Date:  1986 Mar-Apr       Impact factor: 8.090

10.  Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters.

Authors:  M Pocchiari; S Schmittinger; C Masullo
Journal:  J Gen Virol       Date:  1987-01       Impact factor: 3.891
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  2 in total

1.  Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals.

Authors:  R Demaimay; K T Adjou; V Beringue; S Demart; C I Lasmézas; J P Deslys; M Seman; D Dormont
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

Review 2.  Prions and related neurological diseases.

Authors:  M Pocchiari
Journal:  Mol Aspects Med       Date:  1994
  2 in total

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