Literature DB >> 1929305

Evaluation of the hepatotoxic potential of minocycline.

R Böcker1, C J Estler, D Ludewig-Sandig.   

Abstract

Minocycline (25 to 100 micrograms/g) dose dependently increased serum glutamic oxalacetic transaminase, urea, and bilirubin levels, and the hepatic triglyceride content in mice. In animals pretreated with phenobarbital to enhance minocycline metabolism, the effects on liver triglycerides were attenuated, while the changes in serum glutamic oxalacetic transaminase, urea, and bilirubin were enhanced. It is concluded that part of the toxic effects of minocycline may be produced by a metabolite of minocycline.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1929305      PMCID： PMC245185          DOI： 10.1128/AAC.35.7.1434

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  A rapid and precise method for the determination of urea.

Authors:  J K FAWCETT; J E SCOTT
Journal:  J Clin Pathol       Date:  1960-03       Impact factor: 3.411

2.  Unique metabolic fate of a tetracycline (minocycline)

Authors:  H J Nelis; A P de Leenheer
Journal:  Lancet       Date:  1981-10-24       Impact factor: 79.321

3.  Comparative evaluation of the effects of tetracycline and doxycycline on blood and liver lipids on male and female mice.

Authors:  R Böcker; C J Estler; M Maywald; D Weber
Journal:  Arzneimittelforschung       Date:  1981

4.  Acute hepatic injury associated with minocycline.

Authors:  A Burette; C Finet; T Prigogine; G De Roy; M Deltenre
Journal:  Arch Intern Med       Date:  1984-07

5.  Liquid chromatographic determination of minocycline in human serum.

Authors:  A P De Leenheer; H J Nelis
Journal:  J Pharm Sci       Date:  1979-12       Impact factor: 3.534

6.  Comparative evaluation of the effects of tetracycline, rolitetracycline and doxycycline on some blood parameters related to liver function.

Authors:  R Böcker; C J Estler; S Müller; C Pfandzelter; B Spachmüller
Journal:  Arzneimittelforschung       Date:  1982
  6 in total
  8 in total

Review 1.  Tetracyclines and pain.

Authors:  Leandro F S Bastos; Antônio C P de Oliveira; Linda R Watkins; Márcio F D Moraes; Márcio M Coelho
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-01-27       Impact factor: 3.000

Review 2.  Neuroinflammation in hepatic encephalopathy: mechanistic aspects.

Authors:  Arumugam R Jayakumar; Kakulavarapu V Rama Rao; Michael D Norenberg
Journal:  J Clin Exp Hepatol       Date:  2014-08-05

3.  Effects of minocycline on Fas-mediated fulminant hepatitis in mice.

Authors:  Heng-Cheng Chu; Yi-Ling Lin; Huey-Kang Sytwu; Shin-Hua Lin; Ching-Len Liao; You-Chen Chao
Journal:  Br J Pharmacol       Date:  2005-01       Impact factor: 8.739

4.  Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir.

Authors:  Robert DiCenzo; Derick R Peterson; Kim Cruttenden; Peter Mariuz; Naser L Rezk; Jill Hochreiter; Harris Gelbard; Giovanni Schifitto
Journal:  Antimicrob Agents Chemother       Date:  2008-06-23       Impact factor: 5.191

5.  Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance.

Authors:  Tim Frenzel; Chanhung Z Lee; Helen Kim; Nancy J Quinnine; Tomoki Hashimoto; Michael T Lawton; B Joseph Guglielmo; Charles E McCulloch; William L Young
Journal:  Cerebrovasc Dis       Date:  2008-01-23       Impact factor: 2.762

6.  Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome.

Authors:  A Gough; S Chapman; K Wagstaff; P Emery; E Elias
Journal:  BMJ       Date:  1996-01-20

7.  Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock/resuscitation.

Authors:  Andaleb Kholmukhamedov; Christoph Czerny; Jiangting Hu; Justin Schwartz; Zhi Zhong; John J Lemasters
Journal:  Shock       Date:  2014-09       Impact factor: 3.454

8.  Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.

Authors:  Maria Teresa Ferretti; Simon Allard; Vanessa Partridge; Adriana Ducatenzeiler; A Claudio Cuello
Journal:  J Neuroinflammation       Date:  2012-04-02       Impact factor: 8.322
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.