Literature DB >> 19292989

Xeomin is free from complexing proteins.

Jürgen Frevert1.   

Abstract

In contrast to the other botulinum toxin products Xeomin only contains the 150kD neurotoxin without complexing proteins which have no therapeutic function and don't influence the diffusion of the neurotoxin. In large clinical Phase III studies (blepharospasm and cervical dystonia) Xeomin showed the same efficacy and profile of adverse events as Botox. Whereas competing product must be stored refrigerated, Xeomin is stable for 3years at room temperature.

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Year:  2009        PMID: 19292989     DOI: 10.1016/j.toxicon.2009.03.010

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  23 in total

1.  Efficacy and safety of higher doses of botulinum toxin type A NT 201 free from complexing proteins in the upper and lower limb spasticity after stroke.

Authors:  Andrea Santamato; Francesco Panza; Maurizio Ranieri; Vincenza Frisardi; Maria Francesca Micello; Serena Filoni; Francesca Fortunato; Domenico Intiso; Mario Basciani; Giancarlo Logroscino; Pietro Fiore
Journal:  J Neural Transm (Vienna)       Date:  2012-09-07       Impact factor: 3.575

2.  Comparative evaluation of the potency and antigenicity of two distinct BoNT/A-derived formulations.

Authors:  M Brown; G Nicholson; M C Ardila; A Satorius; R S Broide; K Clarke; T Hunt; J Francis
Journal:  J Neural Transm (Vienna)       Date:  2012-07-29       Impact factor: 3.575

3.  Onabotulinumtoxin type A (Botox(®)) versus Incobotulinumtoxin type A (Xeomin(®)) in the treatment of focal idiopathic palmar hyperhidrosis: results of a comparative double-blind clinical trial.

Authors:  A Campanati; K Giuliodori; E Martina; A Giuliano; G Ganzetti; A Offidani
Journal:  J Neural Transm (Vienna)       Date:  2013-09-20       Impact factor: 3.575

Review 4.  Treating glabellar lines with botulinum toxin type A-hemagglutinin complex: a review of the science, the clinical data, and patient satisfaction.

Authors:  Koenraad De Boulle; Steven Fagien; Boris Sommer; Richard Glogau
Journal:  Clin Interv Aging       Date:  2010-04-26       Impact factor: 4.458

5.  Blepharospasm: long-term treatment with either Botox®, Xeomin® or Dysport®.

Authors:  Katja Kollewe; Bahram Mohammadi; Steffen Köhler; Heidrun Pickenbrock; Reinhard Dengler; Dirk Dressler
Journal:  J Neural Transm (Vienna)       Date:  2014-07-25       Impact factor: 3.575

Review 6.  Clinical relevance of botulinum toxin immunogenicity.

Authors:  Reiner Benecke
Journal:  BioDrugs       Date:  2012-04-01       Impact factor: 5.807

7.  Evaluating botulinum toxin products for clinical use requires accurate, complete, and unbiased data.

Authors:  Andy Pickett
Journal:  Clin Ophthalmol       Date:  2011-09-09

8.  Efficacy and Safety of IncobotulinumtoxinA in Subjects Previously Treated with Botulinum Toxin Versus Toxin-Naïve Subjects with Cervical Dystonia.

Authors:  Hubert H Fernandez; Eric J Pappert; Cynthia L Comella; Virgilio Gerald H Evidente; Daniel D Truong; Amit Verma; Joseph Jankovic
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2013-04-18

9.  Long-term efficacy and safety of incobotulinumtoxinA injections in patients with cervical dystonia.

Authors:  Dirk Dressler; Sebastian Paus; Andrea Seitzinger; Bernd Gebhardt; Andreas Kupsch
Journal:  J Neurol Neurosurg Psychiatry       Date:  2013-05-18       Impact factor: 10.154

10.  Diffusion of botulinum toxins.

Authors:  Matthew A Brodsky; David M Swope; David Grimes
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2012-08-06
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