| Literature DB >> 19292769 |
N Bagnall1, J Gough, L Cadogan, B Burns, K Kongsuwan.
Abstract
It is widely acknowledged that changes in intracellular calcium ion (Ca(2+)) concentration provide dynamic signals that control a plethora of cellular processes, including triggering and mediating host defence mechanisms. In this study, quantitative real-time PCR was used to analyse gene expression of 14 Ca(2+) signalling proteins in skin obtained from high tick-resistant (HR) and low tick-resistant (LR) cattle following artificial challenge with cattle tick (Rhipicephalus (Boophilus) microplus). Up-regulation of numerous genes was observed in both HR and LR skin following tick challenge, however substantially higher transcription activation was found in HR tissue. The elevated expression in HR skin of specific Ca(2+) signalling genes such as AHNAK, CASQ, IL2, NFAT2CIP and PLCG1 may be related to host resistance. Our data suggest that Ca(2+) and its associated proteins might play an important role in host response to ticks and that further investigation is warranted.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19292769 DOI： 10.1111/j.1365-3024.2008.01092.x
Source DB: PubMed Journal: Parasite Immunol ISSN： 0141-9838 Impact factor: 2.280