Literature DB >> 1929271

Accidental overdose of intravenous ofloxacin with benign outcome.

R B Kohler1, N Arkins, K J Tack.   

Abstract

A patient accidentally received approximately 3 g of ofloxacin intravenously. She experienced only moderately severe central nervous system symptoms, which resolved within 9 h. The peak serum ofloxacin level was 39.3 micrograms/ml, approximately seven times the usual peak level. Ofloxacin may possess a considerable safety margin in humans.

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Year:  1991        PMID： 1929271      PMCID： PMC284320          DOI： 10.1128/AAC.35.6.1239

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites.

Authors:  K Akahane; M Sekiguchi; T Une; Y Osada
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

Review 2.  Quinolone antimicrobial agents: adverse effects and bacterial resistance.

Authors:  J S Wolfson
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-12       Impact factor: 3.267

3.  Psychotoxic effects of ofloxacin.

Authors:  M Zaudig; M von Bose; M M Weber; D Bremer; W Zieglgänsberger
Journal:  Pharmacopsychiatry       Date:  1989-01       Impact factor: 5.788

4.  Norfloxacin and seizures.

Authors:  G D Anastasio; D Menscer; J M Little
Journal:  Ann Intern Med       Date:  1988-07-15       Impact factor: 25.391

5.  Convulsions related to enoxacin.

Authors:  K J Simpson; M J Brodie
Journal:  Lancet       Date:  1985-07-20       Impact factor: 79.321

Review 6.  Efficacy, safety, and potential economic benefits of oral ciprofloxacin in the treatment of infections.

Authors:  W E Sanders
Journal:  Rev Infect Dis       Date:  1988 May-Jun

7.  Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor.

Authors:  S Segev; M Rehavi; E Rubinstein
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

8.  Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.

Authors:  A Tsuji; H Sato; Y Kume; I Tamai; E Okezaki; O Nagata; H Kato
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

9.  [Adverse drug interactions between pyridonecarboxylic acids and nonsteroidal antiinflammatory drugs: convulsion after oral or intracerebral administration in mice].

Authors:  S Hirai; K Tanaka; S Makino; H Narita
Journal:  Yakugaku Zasshi       Date:  1989-02       Impact factor: 0.302

Review 10.  Adverse reactions and interactions of fluoroquinolones.

Authors:  P Ball
Journal:  Clin Invest Med       Date:  1989-02       Impact factor: 0.825
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  2 in total

Review 1.  Tolerability of fluoroquinolone antibiotics. Past, present and future.

Authors:  P Ball; G Tillotson
Journal:  Drug Saf       Date:  1995-12       Impact factor: 5.606

Review 2.  Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use.

Authors:  P A Todd; D Faulds
Journal:  Drugs       Date:  1991-11       Impact factor: 9.546
  2 in total

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