Literature DB >> 1929222

Use of computed tomography, magnetic resonance imaging, and localized 1H magnetic resonance spectroscopy in Canavan's disease: a case report.

H G Marks1, P A Caro, Z Y Wang, J A Detre, A R Bogdan, D A Gusnard, R A Zimmerman.   

Abstract

The neuroradiological evaluation of Canavan's disease in a 38-month-old girl is discussed. Computed tomography showed diffuse symmetrical low attenuation values of the subcortical and deep cerebral white matter. Magnetic resonance imaging demonstrated symmetrical diffuse low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. With the use of 1H magnetic resonance spectroscopy, we were able to show elevated levels of N-acetylaspartic acid in the occipital lobe of our patient. The in vivo measurement of N-acetylaspartic acid in the brain by 1H magnetic resonance spectroscopy offers an additional noninvasive diagnostic test for establishing the diagnosis of Canavan's disease. With the increasing availability of magnetic resonance spectroscopy, clinicians may be able to confirm the diagnosis of Canavan's disease immediately after magnetic resonance imaging reveals the typical abnormalities of the white matter.

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Year:  1991        PMID： 1929222     DOI： 10.1002/ana.410300120

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  10 in total

1.  Van der Knaap disease: a rare disease with atypical features.

Authors:  Ujjawal Roy; Bhushan Joshi; Goutam Ganguly
Journal:  BMJ Case Rep       Date:  2015-07-23

2.  Infantile-onset leukoencephalopathy with discrepant mild clinical course.

Authors:  S Gulati; M Kabra; S Gera; M Ghosh; P S Menon; V Kalra
Journal:  Indian J Pediatr       Date:  2000-10       Impact factor: 1.967

3.  Megalencephalic leucoencephalopathy with subcortical cysts: subcortical diffuse leucoencephalopathy associated with white matter cystic degeneration.

Authors:  Prafulla Kumar Dash; Dinesh Harvey Raj; Hrushikesh Sahu
Journal:  BMJ Case Rep       Date:  2015-09-21

Review 4.  Proton magnetic resonance spectroscopy in brain white matter disorders.

Authors:  N De Stefano; A Federico; D L Arnold
Journal:  Ital J Neurol Sci       Date:  1997-12

5.  Cranial ultrasound findings in aspartoacylase deficiency (Canavan disease).

Authors:  C Bührer; C Bassir; A von Moers; J Sperner; T Michael; D Scheffner; H J Kaufmann
Journal:  Pediatr Radiol       Date:  1993

6.  Magnetic resonance imaging in juvenile Canavan disease.

Authors:  P B Toft; R Geiss-Holtorff; M O Rolland; O Pryds; W Müller-Forell; E Christensen; W Lehnert; H C Lou; D Ott; J Hennig
Journal:  Eur J Pediatr       Date:  1993-09       Impact factor: 3.183

Review 7.  What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy?

Authors:  J Vion-Dury; D J Meyerhoff; P J Cozzone; M W Weiner
Journal:  J Neurol       Date:  1994-05       Impact factor: 4.849

8.  Proton magnetic resonance spectroscopic imaging in the clinical evaluation of patients with Niemann-Pick type C disease.

Authors:  G Tedeschi; S Bonavita; N W Barton; A Betolino; J A Frank; N J Patronas; J R Alger; R Schiffmann
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-07       Impact factor: 10.154

9.  Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS).

Authors:  Franz Josef Söbbeler; Inés Carrera; Kirby Pasloske; Millagahamada Gedara Ranasinghe; Patrick Kircher; Sabine Beate Rita Kästner
Journal:  BMC Vet Res       Date:  2018-03-05       Impact factor: 2.741

10.  Megalencephalic leukoencephalopathy with subcortical cysts in all three siblings of a non-Aggarwal Indian family.

Authors:  Mani Kant Kumar; Brish Bhanu Singh
Journal:  Ann Indian Acad Neurol       Date:  2012-07       Impact factor: 1.383
  10 in total

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