Literature DB >> 19291918

The effect of water extracts of Euphorbia hirta on cartilage degeneration in arthritic rats.

Kah Heng Lee1, Yu Sui Chen, John Paul Judson, Srikumar Chakravarthi, Yen Mi Sim, Hui Meng Er.   

Abstract

The effect of water extracts of Euphorbia hirta on the histological features and expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in the rat articular cartilage was investigated. Arthritis was induced in rats using Freund's Complete Adjuvant containing heat-killed M. tuberculosis, and treated with water extracts of E. hirta. Paraffin tissue sections of the arthritic joints were evaluated. The extent of cartilage degeneration was found to be greatest in rats treated with the highest dosage of E. hirta, followed by rats in the untreated group. Rats treated with the intermediary and low dosages of Euphorbia hirta showed improved histology. MMP-13 levels were found to be decreased with decreasing dosages of E. hirta. TIMP-1 levels were found to increase with decreasing dosages of E. hirta. MMP-3 levels fluctuated without any appreciable pattern. Low dosages of E. hirta seem to be beneficial in reducing cartilage degeneration in cases of arthritis.

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Year:  2008        PMID： 19291918

Source DB:  PubMed          Journal:  Malays J Pathol        ISSN： 0126-8635            Impact factor:   0.656


  8 in total

1.  Systemic beneficial effects of Euphorbia besides its immunosuppressive effects.

Authors:  Shailendra Kapoor
Journal:  Inflammopharmacology       Date:  2012-09-21       Impact factor: 4.473

2.  Immunosuppressive effects of Euphorbia hirta in experimental animals.

Authors:  Sheikh Fayaz Ahmad; Beenish Khan; Sarang Bani; Anpurna Kaul; Phalisteen Sultan; Sheikh Abid Ali; N K Satti; Saleh A Bakheet; Sabry M Attia; Khairy M A Zoheir; Adel R A Abd-Allah
Journal:  Inflammopharmacology       Date:  2012-06-19       Impact factor: 4.473

3.  Modulation of Th1 cytokines and inflammatory mediators by Euphorbia hirta in animal model of adjuvant-induced arthritis.

Authors:  Sheikh Fayaz Ahmad; Phalisteen Sultan; Abdelkader E Ashour; Tajdar Husain Khan; Sabry M Attia; Saleh A Bakheet; Adel R A Abd-Allah
Journal:  Inflammopharmacology       Date:  2012-12-11       Impact factor: 4.473

4.  Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.

Authors:  Adeline Yl Lim; Ignacio Segarra; Srikumar Chakravarthi; Sufyan Akram; John P Judson
Journal:  BMC Pharmacol       Date:  2010-10-15

5.  A comparative histopathological study of systemic candidiasis in association with experimentally induced breast cancer.

Authors:  Z W Choo; S Chakravarthi; S F Wong; H S Nagaraja; P M Thanikachalam; J W Mak; A Radhakrishnan; A Tay
Journal:  Oncol Lett       Date:  2010-01-01       Impact factor: 2.967

6.  Amelioration of collagen-induced arthritis in female dark agouti rats by glucosamine treatment.

Authors:  Nagaraja Haleagrahara; Dulanthi Tudawe; Srikumar Chakravarthi; Ammu Kutty Radhakrishnan
Journal:  ISRN Pharmacol       Date:  2013-02-14

7.  Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract.

Authors:  Ching S Tham; Srikumar Chakravarthi; Nagaraja Haleagrahara; Ranjit DE Alwis
Journal:  Exp Ther Med       Date:  2012-12-05       Impact factor: 2.447

8.  Effect of γ-tocotrienol in counteracting oxidative stress and joint damage in collagen-induced arthritis in rats.

Authors:  Ammu Radhakrishnan; Dulanthi Tudawe; Srikumar Chakravarthi; Gan Seng Chiew; Nagaraja Haleagrahara
Journal:  Exp Ther Med       Date:  2014-02-28       Impact factor: 2.447
  8 in total

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