Literature DB >> 19291469

Fatal bupropion overdose with post mortem blood concentrations.

Henry A Spiller1, Edward Bottei, Linda Kalin.   

Abstract

We report five cases of fatal bupropion overdose with post mortem bupropion concentrations ranging from 3.1 to >20 mg/L. Four patients had ingested a sustained-release formulation of bupropion and had evidence of pill "bodies" in their stomach with significantly elevated blood bupropion concentrations. The pills found in these patients may represent the residual matrix/shell with significant portions of the actual bupropion released and absorbed by the patients.

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Year:  2007        PMID: 19291469     DOI: 10.1007/s12024-007-0030-5

Source DB:  PubMed          Journal:  Forensic Sci Med Pathol        ISSN: 1547-769X            Impact factor:   2.007


  14 in total

1.  Tissue distribution of bupropion in a fatal overdose.

Authors:  T P Rohrig; N G Ray
Journal:  J Anal Toxicol       Date:  1992 Sep-Oct       Impact factor: 3.367

2.  Intraventricular conduction delay after bupropion overdose.

Authors:  Steven C Curry; John S Kashani; Frank LoVecchio; William Holubek
Journal:  J Emerg Med       Date:  2005-10       Impact factor: 1.484

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Authors:  C R Harris; J Gualtieri; G Stark
Journal:  J Toxicol Clin Toxicol       Date:  1997

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Authors:  G P Reynolds; J D Elsworth; K Blau; M Sandler; A J Lees; G M Stern
Journal:  Br J Clin Pharmacol       Date:  1978-12       Impact factor: 4.335

5.  Oxycontin: the concept of a "ghost pill" and the postmortem tissue distribution of oxycodone in 36 cases.

Authors:  Daniel T Anderson; Kristina L Fritz; Joseph J Muto
Journal:  J Anal Toxicol       Date:  2002-10       Impact factor: 3.367

6.  Bupropion exposures: clinical manifestations and medical outcome.

Authors:  Martin G Belson; Todd R Kelley
Journal:  J Emerg Med       Date:  2002-10       Impact factor: 1.484

7.  Bupropion overdose: QTc prolongation and its clinical significance.

Authors:  Geoffrey K Isbister; Corrine R Balit
Journal:  Ann Pharmacother       Date:  2003 Jul-Aug       Impact factor: 3.154

8.  Intentional bupropion overdoses.

Authors:  Greene Shepherd; Larissa I Velez; Daniel C Keyes
Journal:  J Emerg Med       Date:  2004-08       Impact factor: 1.484

9.  Bupropion poisoning: a case series.

Authors:  Corrine R Balit; Christa N Lynch; Geoffrey K Isbister
Journal:  Med J Aust       Date:  2003-01-20       Impact factor: 7.738

10.  Sustained release bupropion overdose: an important cause of prolonged symptoms after an overdose.

Authors:  F Jepsen; J Matthews; F J Andrews
Journal:  Emerg Med J       Date:  2003-11       Impact factor: 2.740

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