OBJECTIVE: We evaluated the early pharmacodynamic profile of the combined 30 mg intravenous and 1 mg/kg subcutaneous enoxaparin loading utilized in the TIMI 11B and ExTRACT TIMI 25 trials. BACKGROUND: It has not been reported whether anti-Xa levels appropriate for percutaneous coronary intervention (PCI) can be reliably achieved within 2 h utilizing this regimen. METHODS: Twenty-six patients with acute coronary syndrome (ACS) treated with this regimen had anti-Xa levels measured at 5 min, 2, 4, 6 and 8 h. RESULTS: Seventy-six percent of patients had anti-Xa levels above 0.5 IU/ml at 5 min. Dose-response curves showed all patients to have anti-Xa levels above 0.5 IU/ml within 1 h. Anti-Xa remained in the targeted range for PCI (0.5 to 1.8 IU/ml) at 2, 4, 6 and 8 h in all patients. CONCLUSION: This regimen is well suited for ACS treatment with an invasive strategy, including the rapid transition to early and rescue PCI.
OBJECTIVE: We evaluated the early pharmacodynamic profile of the combined 30 mg intravenous and 1 mg/kg subcutaneous enoxaparin loading utilized in the TIMI 11B and ExTRACT TIMI 25 trials. BACKGROUND: It has not been reported whether anti-Xa levels appropriate for percutaneous coronary intervention (PCI) can be reliably achieved within 2 h utilizing this regimen. METHODS: Twenty-six patients with acute coronary syndrome (ACS) treated with this regimen had anti-Xa levels measured at 5 min, 2, 4, 6 and 8 h. RESULTS: Seventy-six percent of patients had anti-Xa levels above 0.5 IU/ml at 5 min. Dose-response curves showed all patients to have anti-Xa levels above 0.5 IU/ml within 1 h. Anti-Xa remained in the targeted range for PCI (0.5 to 1.8 IU/ml) at 2, 4, 6 and 8 h in all patients. CONCLUSION: This regimen is well suited for ACS treatment with an invasive strategy, including the rapid transition to early and rescue PCI.
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Authors: C P Cannon; W S Weintraub; L A Demopoulos; R Vicari; M J Frey; N Lakkis; F J Neumann; D H Robertson; P T DeLucca; P M DiBattiste; C M Gibson; E Braunwald Journal: N Engl J Med Date: 2001-06-21 Impact factor: 91.245
Authors: Silvio Zalc; Pedro A Lemos; Antonio Esteves; Expedito E Ribeiro; Pedro Horta; Jose C Nicolau; Jose A F Ramires; Marc Cohen; Eulogio E Martinez Journal: J Invasive Cardiol Date: 2006-02 Impact factor: 2.022
Authors: D J Kereiakes; C Grines; E Fry; P Esente; D Hoppensteadt; M Midei; L Barr; W Matthai; M Todd; T Broderick; R Rubinstein; J Fareed; E Santoian; A Neiderman; B Brodie; J Zidar; J J Ferguson; M Cohen Journal: J Invasive Cardiol Date: 2001-04 Impact factor: 2.022
Authors: Gilles Montalescot; Marc Cohen; Genevieve Salette; Walter J Desmet; Carlos Macaya; Philip E G Aylward; Ph Gabriel Steg; Harvey D White; Richard Gallo; Steven R Steinhubl Journal: Eur Heart J Date: 2008-02 Impact factor: 29.983
Authors: James J Ferguson; Robert M Califf; Elliott M Antman; Marc Cohen; Cindy L Grines; Shaun Goodman; Dean J Kereiakes; Anatoly Langer; Kenneth W Mahaffey; Christopher C Nessel; Paul W Armstrong; Alvaro Avezum; Phil Aylward; Richard C Becker; Luigi Biasucci; Steven Borzak; Jacques Col; Marty J Frey; Ed Fry; Dietrich C Gulba; Sema Guneri; Enrique Gurfinkel; Robert Harrington; Judith S Hochman; Neal S Kleiman; Martin B Leon; Jose Luis Lopez-Sendon; Carl J Pepine; Witold Ruzyllo; Steven R Steinhubl; Paul S Teirstein; Luis Toro-Figueroa; Harvey White Journal: JAMA Date: 2004-07-07 Impact factor: 56.272
Authors: C Michael Gibson; Sabina A Murphy; Gilles Montalescot; David A Morrow; Diego Ardissino; Marc Cohen; Dietrich C Gulba; Oscar H Kracoff; Basil S Lewis; Nathan Roguin; Elliott M Antman; Eugene Braunwald Journal: J Am Coll Cardiol Date: 2007-05-25 Impact factor: 24.094
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