Literature DB >> 19290786

Pharmacogenetics of the organic anion transporting polypeptide 1A2.

Ryan M Franke1, Lisa A Scherkenbach, Alex Sparreboom.   

Abstract

The solute carrier, human organic anion transporting polypeptide 1A2 (OATP1A2, OATP-A, OATP1 and OATP) is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. This localization suggests that OATP1A2 may be vitally important in the absorption, distribution and excretion of a broad array of clinically important drugs. Several nonsynonymous polymorphisms have been identified in the gene encoding OATP1A2, SLCO1A2 (SLC21A3), with some of these variants demonstrating functional changes in the transport of OATP1A2 substrates.

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Year:  2009        PMID： 19290786      PMCID： PMC4865796          DOI： 10.2217/14622416.10.3.339

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  33 in total

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Journal:  J Hum Genet       Date:  2001       Impact factor: 3.172

2.  Multispecific amphipathic substrate transport by an organic anion transporter of human liver.

Authors:  X Bossuyt; M Müller; P J Meier
Journal:  J Hepatol       Date:  1996-11       Impact factor: 25.083

3.  Regional distribution of solute carrier mRNA expression along the human intestinal tract.

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Journal:  Drug Metab Dispos       Date:  2007-01-12       Impact factor: 3.922

4.  Inhibition of imatinib transport by uremic toxins during renal failure.

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5.  Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

Authors:  I Tamai; J Nezu; H Uchino; Y Sai; A Oku; M Shimane; A Tsuji
Journal:  Biochem Biophys Res Commun       Date:  2000-06-24       Impact factor: 3.575

Review 6.  Hepatic transport of bile salts.

Authors:  G A Kullak-Ublick; B Stieger; B Hagenbuch; P J Meier
Journal:  Semin Liver Dis       Date:  2000       Impact factor: 6.115

7.  Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.

Authors:  Ilaria Badagnani; Richard A Castro; Travis R Taylor; Claire M Brett; Conrad C Huang; Douglas Stryke; Michiko Kawamoto; Susan J Johns; Thomas E Ferrin; Elaine J Carlson; Esteban G Burchard; Kathleen M Giacomini
Journal:  J Pharmacol Exp Ther       Date:  2006-05-15       Impact factor: 4.030

8.  Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.

Authors:  G A Kullak-Ublick; T Fisch; M Oswald; B Hagenbuch; P J Meier; U Beuers; G Paumgartner
Journal:  FEBS Lett       Date:  1998-03-13       Impact factor: 4.124

9.  Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

Authors:  Oscar Briz; Maria A Serrano; Rocio I R MacIas; Javier Gonzalez-Gallego; Jose J G Marin
Journal:  Biochem J       Date:  2003-05-01       Impact factor: 3.857

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Journal:  Pflugers Arch       Date:  2003-11-18       Impact factor: 3.657
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  21 in total

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Authors:  Tristan M Sissung; Sarah M Troutman; Tessa J Campbell; Heather M Pressler; Hyeyoung Sung; Susan E Bates; William D Figg
Journal:  Discov Med       Date:  2012-01       Impact factor: 2.970

2.  The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries.

Authors:  A C C Costa; E B Coelho; V L Lanchote; B V Correia; J T Abumansur; G R Lauretti; N V de Moraes
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4.  Levofloxacin-induced seizures in a patient without predisposing risk factors: the impact of pharmacogenetics.

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5.  Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2.

Authors:  Fanfan Zhou; Andy C Lee; Katja Krafczyk; Ling Zhu; Michael Murray
Journal:  Br J Pharmacol       Date:  2011-03       Impact factor: 8.739

Review 6.  Role of CAR and PXR in xenobiotic sensing and metabolism.

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Journal:  Expert Opin Drug Metab Toxicol       Date:  2012-05-03       Impact factor: 4.481

7.  Environmental and genetic factors affecting transport of imatinib by OATP1A2.

Authors:  K Eechoute; R M Franke; W J Loos; L A Scherkenbach; I Boere; J Verweij; H Gurney; R B Kim; R G Tirona; R H J Mathijssen; A Sparreboom
Journal:  Clin Pharmacol Ther       Date:  2011-04-20       Impact factor: 6.875

Review 8.  Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs.

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9.  Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).

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Journal:  Nat Rev Gastroenterol Hepatol       Date:  2016-04-20       Impact factor: 46.802

10.  The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.

Authors:  N Picard; S W Yee; J-B Woillard; Y Lebranchu; Y Le Meur; K M Giacomini; P Marquet
Journal:  Clin Pharmacol Ther       Date:  2009-11-04       Impact factor: 6.875
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