Literature DB >> 19289523

Inhaled voriconazole for prevention of invasive pulmonary aspergillosis.

Justin A Tolman1, Nathan P Wiederhold, Jason T McConville, Laura K Najvar, Rosie Bocanegra, Jay I Peters, Jacqueline J Coalson, John R Graybill, Thomas F Patterson, Robert O Williams.   

Abstract

Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.

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Year:  2009        PMID： 19289523      PMCID： PMC2687213          DOI： 10.1128/AAC.01657-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation.

Authors:  B D Alexander; E S Dodds Ashley; R M Addison; J A Alspaugh; N J Chao; J R Perfect
Journal:  Transpl Infect Dis       Date:  2006-03       Impact factor: 2.228

2.  Standardization of an experimental murine model of invasive pulmonary aspergillosis.

Authors:  Donald C Sheppard; John R Graybill; Laura K Najvar; Lisa Y Chiang; Thomas Doedt; William R Kirkpatrick; Rosie Bocanegra; Ana C Vallor; Thomas F Patterson; Scott G Filler
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

3.  Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.

Authors:  Nathan P Wiederhold; Laura K Najvar; Ana C Vallor; William R Kirkpatrick; Rosie Bocanegra; Destiny Molina; Marcos Olivo; John R Graybill; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2007-12-26       Impact factor: 5.191

4.  Characterization and pharmacokinetic analysis of aerosolized aqueous voriconazole solution.

Authors:  Justin A Tolman; Nicole A Nelson; Yoen Ju Son; Stephanie Bosselmann; Nathan P Wiederhold; Jay I Peters; Jason T McConville; Robert O Williams
Journal:  Eur J Pharm Biopharm       Date:  2009-05       Impact factor: 5.571

Review 5.  Invasive aspergillosis.

Authors:  D W Denning
Journal:  Clin Infect Dis       Date:  1998-04       Impact factor: 9.079

6.  A survey of anti-fungal management in lung transplantation.

Authors:  J Stephen Dummer; Nikoloz Lazariashvilli; Jean Barnes; Mathew Ninan; Aaron P Milstone
Journal:  J Heart Lung Transplant       Date:  2004-12       Impact factor: 10.247

7.  Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate.

Authors:  J C Bowman; G K Abruzzo; J W Anderson; A M Flattery; C J Gill; V B Pikounis; D M Schmatz; P A Liberator; C M Douglas
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

Review 8.  Aspergillosis case-fatality rate: systematic review of the literature.

Authors:  S J Lin; J Schranz; S M Teutsch
Journal:  Clin Infect Dis       Date:  2001-01-26       Impact factor: 9.079

9.  Novel inhalational murine model of invasive pulmonary aspergillosis.

Authors:  Donald C Sheppard; Gunter Rieg; Lisa Y Chiang; Scott G Filler; John E Edwards; Ashraf S Ibrahim
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

10.  Aerosolized liposomal amphotericin B for the prevention of invasive pulmonary aspergillosis during prolonged neutropenia: a randomized, placebo-controlled trial.

Authors:  Bart J Rijnders; Jan J Cornelissen; Lennert Slobbe; Martin J Becker; Jeanette K Doorduijn; Wim C J Hop; Elisabeth J Ruijgrok; Bob Löwenberg; Arnold Vulto; Pieternella J Lugtenburg; Siem de Marie
Journal:  Clin Infect Dis       Date:  2008-05-01       Impact factor: 9.079
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  9 in total

1.  Pulmonary injury after combined exposures to low-dose low-LET radiation and fungal spores.

Authors:  B Marples; L Downing; K E Sawarynski; J N Finkelstein; J P Williams; A A Martinez; G D Wilson; M D Sims
Journal:  Radiat Res       Date:  2011-01-28       Impact factor: 2.841

Review 2.  Clinical pharmacokinetics of inhaled antimicrobials.

Authors:  Chris Stockmann; Jessica K Roberts; Venkata K Yellepeddi; Catherine M T Sherwin
Journal:  Clin Pharmacokinet       Date:  2015-05       Impact factor: 6.447

3.  Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin.

Authors:  Elena Appel; Alexandra Vallon-Eberhard; Aharon Rabinkov; Ori Brenner; Irina Shin; Keren Sasson; Yona Shadkchan; Nir Osherov; Steffen Jung; David Mirelman
Journal:  Antimicrob Agents Chemother       Date:  2009-11-30       Impact factor: 5.191

Review 4.  Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead.

Authors:  Tony Velkov; Nusaibah Abdul Rahim; Qi Tony Zhou; Hak-Kim Chan; Jian Li
Journal:  Adv Drug Deliv Rev       Date:  2014-11-12       Impact factor: 15.470

5.  In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice.

Authors:  Genki Kimura; Takahiro Nakaoki; Thomas Colley; Garth Rapeport; Pete Strong; Kazuhiro Ito; Yasuo Kizawa
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

6.  In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris.

Authors:  Shivaprakash M Rudramurthy; Thomas Colley; Alireza Abdolrasouli; Jed Ashman; Manpreet Dhaliwal; Harsimran Kaur; Darius Armstrong-James; Pete Strong; Garth Rapeport; Silke Schelenz; Kazuhiro Ito; Arunaloke Chakrabarti
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

7.  Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus.

Authors:  Thomas Colley; Cheshta Sharma; Alexandre Alanio; Genki Kimura; Leah Daly; Takahiro Nakaoki; Yuki Nishimoto; Stéphane Bretagne; Yasuo Kizawa; Pete Strong; Garth Rapeport; Kazuhiro Ito; Jacques F Meis; Anuradha Chowdhary
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

8.  Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention.

Authors:  Ranjot Kaur; Sarah R Dennison; Andrea J Burrow; Shivaprakash M Rudramurthy; Rajan Swami; Varun Gorki; O P Katare; Anupama Kaushik; Bhupinder Singh; Kamalinder K Singh
Journal:  J Nanobiotechnology       Date:  2021-01-11       Impact factor: 10.435

Review 9.  Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections.

Authors:  Kévin Brunet; Jean-Philippe Martellosio; Frédéric Tewes; Sandrine Marchand; Blandine Rammaert
Journal:  Pharmaceutics       Date:  2022-03-14       Impact factor: 6.321
  9 in total

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