| Literature DB >> 19289119 |
Mie Hirohata1, Kenjiro Ono, Akiyoshi Morinaga, Tokuhei Ikeda, Masahito Yamada.
Abstract
The alpha-synuclein aggregation in the brain is the hallmark of Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies, and multiple system atrophy. Some epidemiological studies have revealed that estrogen therapy reduces the risk of Parkinson's disease in females. We examined the effects of estriol, estradiol, estrone, androstenedione, and testosterone on the formation and destabilization of alpha-synuclein fibrils at pH 7.5 and 37 degrees C in vitro, using fluorescence spectroscopy with thioflavin S and electron microscopy. These sex hormones, especially estriol, significantly exert anti-aggregation and fibril-destabilizing effects; and hence, could be valuable preventive and therapeutic agents for alpha-synucleinopathies.Entities:
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Year: 2009 PMID： 19289119 DOI： 10.1016/j.expneurol.2009.03.003
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330