Literature DB >> 19287391

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.

David J Loane1, Ana Pocivavsek, Charbel E-H Moussa, Rachel Thompson, Yasuji Matsuoka, Alan I Faden, G William Rebeck, Mark P Burns.   

Abstract

Amyloid-beta (Abeta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.

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Year:  2009        PMID： 19287391      PMCID： PMC2844765          DOI： 10.1038/nm.1940

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  29 in total

1.  Head trauma and the risk of Alzheimer's disease.

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Journal:  Am J Epidemiol       Date:  1992-04-01       Impact factor: 4.897

2.  Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.

Authors:  Thiruma V Arumugam; Sic L Chan; Dong-Gyu Jo; Gokhan Yilmaz; Sung-Chun Tang; Aiwu Cheng; Marc Gleichmann; Eitan Okun; Vishwa D Dixit; Srinivasulu Chigurupati; Mohamed R Mughal; Xin Ouyang; Lucio Miele; Tim Magnus; Suresh Poosala; D Neil Granger; Mark P Mattson
Journal:  Nat Med       Date:  2006-05-07       Impact factor: 53.440

3.  Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

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Journal:  Science       Date:  1989-07-28       Impact factor: 47.728

4.  Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.

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Journal:  Nature       Date:  1996-10-24       Impact factor: 49.962

5.  beta A4 amyloid protein deposition in brain after head trauma.

Authors:  G W Roberts; S M Gentleman; A Lynch; D I Graham
Journal:  Lancet       Date:  1991-12-07       Impact factor: 79.321

6.  Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

Authors:  G W Roberts; S M Gentleman; A Lynch; L Murray; M Landon; D I Graham
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-04       Impact factor: 10.154

7.  Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first-degree relatives.

Authors:  R Mayeux; R Ottman; M X Tang; L Noboa-Bauza; K Marder; B Gurland; Y Stern
Journal:  Ann Neurol       Date:  1993-05       Impact factor: 10.422

8.  Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.

Authors:  Milos D Ikonomovic; Kunihiro Uryu; Eric E Abrahamson; John R Ciallella; John Q Trojanowski; Virginia M-Y Lee; Robert S Clark; Donald W Marion; Stephen R Wisniewski; Steven T DeKosky
Journal:  Exp Neurol       Date:  2004-11       Impact factor: 5.330

9.  Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).

Authors:  I Blasko; R Beer; M Bigl; J Apelt; G Franz; D Rudzki; G Ransmayr; A Kampfl; R Schliebs
Journal:  J Neural Transm (Vienna)       Date:  2004-02-04       Impact factor: 3.575

10.  beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.

Authors:  M P Mattson; B Cheng; D Davis; K Bryant; I Lieberburg; R E Rydel
Journal:  J Neurosci       Date:  1992-02       Impact factor: 6.167
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  131 in total

1.  Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer's Disease in a Murine Model.

Authors:  Dandan Lou; Yao Du; Daochao Huang; Fang Cai; Yun Zhang; Tinyu Li; Weihui Zhou; Hongchang Gao; Weihong Song
Journal:  Mol Neurobiol       Date:  2017-08-03       Impact factor: 5.590

2.  Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo.

Authors:  Yingxia Liang; Frank Raven; Joseph F Ward; Sherri Zhen; Siyi Zhang; Haoqi Sun; Sean J Miller; Se Hoon Choi; Rudolph E Tanzi; Can Zhang
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

3.  CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury.

Authors:  Shruti V Kabadi; Bogdan A Stoica; Marie Hanscom; David J Loane; Giorgi Kharebava; Michael G Murray Ii; Rainier M Cabatbat; Alan I Faden
Journal:  Neurotherapeutics       Date:  2012-04       Impact factor: 7.620

4.  BACE2 expression increases in human neurodegenerative disease.

Authors:  Christopher J Holler; Robin L Webb; Ashley L Laux; Tina L Beckett; Dana M Niedowicz; Rachel R Ahmed; Yinxing Liu; Christopher R Simmons; Amy L S Dowling; Angela Spinelli; Moshe Khurgel; Steven Estus; Elizabeth Head; Louis B Hersh; M Paul Murphy
Journal:  Am J Pathol       Date:  2011-11-07       Impact factor: 4.307

5.  BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice.

Authors:  Xiao-Xin Yan; Yan Cai; Xue-Mei Zhang; Xue-Gang Luo; Huaibin Cai; Gregory M Rose; Peter R Patrylo
Journal:  Exp Neurol       Date:  2012-01-11       Impact factor: 5.330

6.  Blood-brain barrier pathophysiology in traumatic brain injury.

Authors:  Adam Chodobski; Brian J Zink; Joanna Szmydynger-Chodobska
Journal:  Transl Stroke Res       Date:  2011-12       Impact factor: 6.829

Review 7.  Boxing-acute complications and late sequelae: from concussion to dementia.

Authors:  Hans Förstl; Christian Haass; Bernhard Hemmer; Bernhard Meyer; Martin Halle
Journal:  Dtsch Arztebl Int       Date:  2010-11-26       Impact factor: 5.594

8.  The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice.

Authors:  Patricia M Washington; Patrick A Forcelli; Tiffany Wilkins; David N Zapple; Maia Parsadanian; Mark P Burns
Journal:  J Neurotrauma       Date:  2012-08-03       Impact factor: 5.269

Review 9.  Dementia resulting from traumatic brain injury: what is the pathology?

Authors:  Sharon Shively; Ann I Scher; Daniel P Perl; Ramon Diaz-Arrastia
Journal:  Arch Neurol       Date:  2012-10

10.  Fluid-percussion-induced traumatic brain injury model in rats.

Authors:  Shruti V Kabadi; Genell D Hilton; Bogdan A Stoica; David N Zapple; Alan I Faden
Journal:  Nat Protoc       Date:  2010-08-19       Impact factor: 13.491
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