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Literature DB >> 19287205

The role of the transcriptional regulator snail in cell detachment, reattachment and migration.

Abstract

In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues and attach to a second site. The transcription factor snail is an important mediator of epithelial-mesenchymal transitions and is involved in tumor progression. Recent data have provided evidence for a requirement for snail expression in metastatic dissemination. Although very little is known about the molecular mechanisms governing metastatic dissemination, we review the possible roles of snail expression in this process. We also review the regulation of snail expression.

Entities: Disease Gene

Mesh：

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Year: 2009 PMID： 19287205 PMCID： PMC2712805 DOI： 10.4161/cam.3.3.8259

Source DB: PubMed Journal: Cell Adh Migr ISSN： 1933-6918 Impact factor: 3.405

70 in total

1. Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins.

Authors: Misako Haraguchi; Tadashi Okubo; Yayoi Miyashita; Yasunori Miyamoto; Masao Hayashi; Tania N Crotti; Kevin P McHugh; Masayuki Ozawa
Journal: J Biol Chem Date: 2008-06-30 Impact factor: 5.157

2. p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.

Authors: Yuen L Pon; Hong Y Zhou; Annie N Y Cheung; Hextan Y S Ngan; Alice S T Wong
Journal: Cancer Res Date: 2008-08-15 Impact factor: 12.701

3. Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.

Authors: María J Blanco; Alejandro Barrallo-Gimeno; Hervé Acloque; Ariel E Reyes; Masazumi Tada; Miguel L Allende; Roberto Mayor; M Angela Nieto
Journal: Development Date: 2007-11 Impact factor: 6.868

4. Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines.

Authors: D Olmeda; A Montes; G Moreno-Bueno; J M Flores; F Portillo; A Cano
Journal: Oncogene Date: 2008-04-14 Impact factor: 9.867

5. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.

Authors: Minna Takkunen; Mari Ainola; Noora Vainionpää; Reidar Grenman; Manuel Patarroyo; Antonio García de Herreros; Yrjö T Konttinen; Ismo Virtanen
Journal: Histochem Cell Biol Date: 2008-05-22 Impact factor: 4.304

6. Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression.

Authors: Y Usami; S Satake; F Nakayama; M Matsumoto; K Ohnuma; T Komori; S Semba; A Ito; H Yokozaki
Journal: J Pathol Date: 2008-07 Impact factor: 7.996

7. Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function.

Authors: Noora Vainionpää; Veli-Pekka Lehto; Karl Tryggvason; Ismo Virtanen
Journal: Lab Invest Date: 2007-06-04 Impact factor: 5.662

8. Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma.

Authors: Koichiro Higashikawa; Shingo Yoneda; Kei Tobiume; Masayuki Taki; Hideo Shigeishi; Nobuyuki Kamata
Journal: Cancer Res Date: 2007-10-01 Impact factor: 12.701

9. Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression.

Authors: Luke S Wanami; Hsin-Ying Chen; Sandra Peiró; Antonio García de Herreros; Robin E Bachelder
Journal: Exp Cell Res Date: 2008-05-17 Impact factor: 3.905

10. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Authors: Kevin G Leong; Kyle Niessen; Iva Kulic; Afshin Raouf; Connie Eaves; Ingrid Pollet; Aly Karsan
Journal: J Exp Med Date: 2007-11-05 Impact factor: 14.307

13 in total

1. Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.

Authors: Liza J Burton; Basil A Smith; Bethany N Smith; Quentin Loyd; Peri Nagappan; Danielle McKeithen; Catera L Wilder; Manu O Platt; Tamaro Hudson; Valerie A Odero-Marah
Journal: Carcinogenesis Date: 2015-06-10 Impact factor: 4.944

The role of the transcriptional regulator snail in cell detachment, reattachment and migration.

1. Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins.

2. p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.

3. Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.

4. Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines.

5. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.

6. Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression.

7. Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function.

8. Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma.

9. Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression.

10. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

1. Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.

2. Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis.

3. Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing.

4. TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.

5. In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes.

Review 6. The Role of Snail-1 in Thyroid Cancer-What We Know So Far.

7. Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells.

8. Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress.

9. Snail mediates invasion through uPA/uPAR and the MAPK signaling pathway in prostate cancer cells.

Review 10. Cancer metastases: challenges and opportunities.