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Literature DB >> 19286809

A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity.

Ana Filipa N Tavares¹, Lígia S Nobre, Ana M P Melo, Lígia M Saraiva.

Abstract

In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that seems to play a dual role in vivo, promoting nitrofuran activation and protecting the cell against transnitrosylation.

Entities: Chemical Gene Species

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Year: 2009 PMID： 19286809 PMCID： PMC2687171 DOI： 10.1128/JB.00022-09

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

11 in total

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