Literature DB >> 19286797

Glycerol utilization gene cluster in Streptomyces clavuligerus.

Sonia Baños1, Rosario Pérez-Redondo, Bert Koekman, Paloma Liras.   

Abstract

The Streptomyces clavuligerus ATCC 27064 glycerol cluster gylR-glpF1K1D1 is induced by glycerol but is not affected by glucose. S. clavuligerus growth and clavulanic acid production are stimulated by glycerol, but this does not occur in a glpK1-deleted mutant. Amplification of glpK1D1 results in transformants yielding larger amounts of clavulanic acid in the wild-type strain and in overproducer S. clavuligerus Gap15-7-30 or S. clavuligerus Delta relA strains.

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Year:  2009        PMID： 19286797      PMCID： PMC2681673          DOI： 10.1128/AEM.00181-09

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  Interaction at a distance between multiple operators controls the adjacent, divergently transcribed glpTQ-glpACB operons of Escherichia coli K-12.

Authors:  T J Larson; J S Cantwell; A T van Loo-Bhattacharya
Journal:  J Biol Chem       Date:  1992-03-25       Impact factor: 5.157

2.  Sequence logos: a new way to display consensus sequences.

Authors:  T D Schneider; R M Stephens
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

3.  Cloning and transcription analysis of the entire glycerol utilization (gylABX) operon of Streptomyces coelicolor A3(2) and identification of a closely associated transcription unit.

Authors:  C P Smith; K F Chater
Journal:  Mol Gen Genet       Date:  1988-01

4.  Structure and regulation of controlling sequences for the Streptomyces coelicolor glycerol operon.

Authors:  C P Smith; K F Chater
Journal:  J Mol Biol       Date:  1988-12-05       Impact factor: 5.469

5.  Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.

Authors:  R Pérez-Redondo; A Rodríguez-García; J F Martín; P Liras
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

6.  Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus.

Authors:  Y Aharonowitz; A L Demain
Journal:  Antimicrob Agents Chemother       Date:  1978-08       Impact factor: 5.191

7.  Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis.

Authors:  K A Aidoo; A Wong; D C Alexander; R A Rittammer; S E Jensen
Journal:  Gene       Date:  1994-09-15       Impact factor: 3.688

8.  Structure and regulation of the glpFK operon encoding glycerol diffusion facilitator and glycerol kinase of Escherichia coli K-12.

Authors:  D L Weissenborn; N Wittekindt; T J Larson
Journal:  J Biol Chem       Date:  1992-03-25       Impact factor: 5.157

9.  Substrate induction and catabolite repression of the Streptomyces coelicolor glycerol operon are mediated through the GylR protein.

Authors:  Z Hindle; C P Smith
Journal:  Mol Microbiol       Date:  1994-06       Impact factor: 3.501

10.  Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.

Authors:  Juan P Gomez-Escribano; Juan F Martín; A Hesketh; M J Bibb; P Liras
Journal:  Microbiology       Date:  2008-03       Impact factor: 2.777
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  6 in total

1.  Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1.

Authors:  Hua Yin; Sihai Xiang; Jianting Zheng; Keqiang Fan; Tingting Yu; Xu Yang; Yanfeng Peng; Haibin Wang; Deqin Feng; Yuanming Luo; Hua Bai; Keqian Yang
Journal:  Appl Environ Microbiol       Date:  2012-02-17       Impact factor: 4.792

2.  Tripartite Regulation of the glpFKD Operon Involved in Glycerol Catabolism by GylR, Crp, and SigF in Mycobacterium smegmatis.

Authors:  Hyun-Ju Bong; Eon-Min Ko; Su-Yeon Song; In-Jeong Ko; Jeong-Il Oh
Journal:  J Bacteriol       Date:  2019-11-20       Impact factor: 3.490

3.  Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps.

Authors:  Xiaoqing Zheng; Qiuxiang Cheng; Fen Yao; Xiaozheng Wang; Lingxin Kong; Bo Cao; Min Xu; Shuangjun Lin; Zixin Deng; Yit-Heng Chooi; Delin You
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-03       Impact factor: 11.205

4.  Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.

Authors:  R Alvarez-Álvarez; A Rodríguez-García; I Santamarta; R Pérez-Redondo; A Prieto-Domínguez; Y Martínez-Burgo; P Liras
Journal:  Microb Biotechnol       Date:  2014-01-22       Impact factor: 5.813

5.  Streptomyces clavuligerus: The Omics Era.

Authors:  Paloma Liras; Juan F Martín
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258

6.  Enhanced production of clavulanic acid by improving glycerol utilization using reporter-guided mutagenesis of an industrial Streptomyces clavuligerus strain.

Authors:  Chang-Hun Shin; Hang Su Cho; Hyung-Jin Won; Ho Jeong Kwon; Chan-Wha Kim; Yeo Joon Yoon
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258
  6 in total

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