Jian-Bo Zhou1, Jin-Kui Yang. 1. Division of Endocrinology and Metabolism, Beijing Tongren Hospital affiliated to Capital Medical University, Beijing, China.
Abstract
INTRODUCTION: We performed a meta-analysis to assess the association of ACE2 G8790A polymorphism with essential hypertension. MATERIALS AND METHODS: The references were retrieved through MEDLINE, Wanfang and VIP Information.The analyses were performed by the software STATA 9.0. RESULTS: No significant publication bias was observed.The combined data showed no association of the frequencies of the A allele with essential hypertension odds ratio (OR)=1.09 95% confidence interval (CI)=0.98-1.20;p=0.11 in female patients. No associations were shown between the frequencies of the A allele with the genetic susceptibility to essential hypertension in male patients (OR=1.11 95% CI=0.95-1.29; p=0.19). CONCLUSION: The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population.
INTRODUCTION: We performed a meta-analysis to assess the association of ACE2G8790A polymorphism with essential hypertension. MATERIALS AND METHODS: The references were retrieved through MEDLINE, Wanfang and VIP Information.The analyses were performed by the software STATA 9.0. RESULTS: No significant publication bias was observed.The combined data showed no association of the frequencies of the A allele with essential hypertension odds ratio (OR)=1.09 95% confidence interval (CI)=0.98-1.20;p=0.11 in female patients. No associations were shown between the frequencies of the A allele with the genetic susceptibility to essential hypertension in male patients (OR=1.11 95% CI=0.95-1.29; p=0.19). CONCLUSION: The meta-analysis suggests that ACE2G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population.
Authors: Sheila K Patel; Elena Velkoska; Melanie Freeman; Bryan Wai; Terase F Lancefield; Louise M Burrell Journal: Front Physiol Date: 2014-06-24 Impact factor: 4.566