OBJECTIVES: To determine the associations between depression, cardiovascular risk factors and coronary artery calcification (CAC) in women with SLE and controls. METHODS: CAC was measured using electron-beam CT (EBCT). Traditional, inflammatory and lupus-related risk factors as well as depressive symptoms (Center for Epidemiologic Studies Depression Scale-CES-D) were measured at a single study visit in 161 women with SLE and 161 age- and race frequency-matched female healthy controls. RESULTS: Women with SLE reported more depressive symptoms than controls, with 27% of SLE and 15% of controls having CES-D scores suggestive of clinical depression. SLE women were more likely to have CAC, as well as more severe CAC compared with controls. Among the SLE women, depression was associated with greater than 2-fold odds of having any CAC [odds ratio (OR) 2.48; 95% CI 1.05, 5.87; P = 0.04], independent of traditional risk factors (age, hypertension and triglycerides) and inflammatory markers. However, when BMI was included among the covariates, the association between depression and CAC was attenuated, indicating the potential mediating role of BMI. Depression was not a risk factor for CAC in controls. CONCLUSIONS: In women with SLE, depression was associated with CAC. This association was mediated by BMI. Depression and adiposity may add to the inflammatory burden of SLE, thus contributing to cardiovascular disease risk.
OBJECTIVES: To determine the associations between depression, cardiovascular risk factors and coronary artery calcification (CAC) in women with SLE and controls. METHODS: CAC was measured using electron-beam CT (EBCT). Traditional, inflammatory and lupus-related risk factors as well as depressive symptoms (Center for Epidemiologic Studies Depression Scale-CES-D) were measured at a single study visit in 161 women with SLE and 161 age- and race frequency-matched female healthy controls. RESULTS:Women with SLE reported more depressive symptoms than controls, with 27% of SLE and 15% of controls having CES-D scores suggestive of clinical depression. SLEwomen were more likely to have CAC, as well as more severe CAC compared with controls. Among the SLEwomen, depression was associated with greater than 2-fold odds of having any CAC [odds ratio (OR) 2.48; 95% CI 1.05, 5.87; P = 0.04], independent of traditional risk factors (age, hypertension and triglycerides) and inflammatory markers. However, when BMI was included among the covariates, the association between depression and CAC was attenuated, indicating the potential mediating role of BMI. Depression was not a risk factor for CAC in controls. CONCLUSIONS: In women with SLE, depression was associated with CAC. This association was mediated by BMI. Depression and adiposity may add to the inflammatory burden of SLE, thus contributing to cardiovascular disease risk.
Authors: Patricia K Agatisa; Karen A Matthews; Joyce T Bromberger; Daniel Edmundowicz; Yue-Fang Chang; Kim Sutton-Tyrrell Journal: Arch Intern Med Date: 2005-06-13
Authors: L H Kuller; K A Matthews; K Sutton-Tyrrell; D Edmundowicz; C H Bunker Journal: Arterioscler Thromb Vasc Biol Date: 1999-09 Impact factor: 8.311
Authors: Yu Asanuma; Cecilia P Chung; Annette Oeser; Ayumi Shintani; Eran Stanley; Paolo Raggi; C Michael Stein Journal: J Rheumatol Date: 2006-02-01 Impact factor: 4.666
Authors: Carol M Greco; Tracy Li; Abdus Sattar; Amy H Kao; Natalya Danchenko; Daniel Edmundowicz; Kim Sutton-Tyrrell; Russell P Tracy; Lewis H Kuller; Susan Manzi Journal: J Rheumatol Date: 2011-12-15 Impact factor: 4.666
Authors: April Jorge; Apinya Lertratanakul; Jungwha Lee; William Pearce; David McPherson; Trina Thompson; Emma Barinas-Mitchell; Rosalind Ramsey-Goldman Journal: Arthritis Care Res (Hoboken) Date: 2016-11-21 Impact factor: 4.794
Authors: Laura J Julian; Chris Tonner; Ed Yelin; Jinoos Yazdany; Laura Trupin; Lindsey A Criswell; Patricia P Katz Journal: Arthritis Care Res (Hoboken) Date: 2011-04 Impact factor: 4.794