| Literature DB >> 19286377 |
Steven M Bromidge1, Barbara Bertani, Manuela Borriello, Andrea Bozzoli, Stefania Faedo, Massimo Gianotti, Laurie J Gordon, Matthew Hill, Valeria Zucchelli, Jeannette M Watson, Laura Zonzini.
Abstract
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones have been identified as highly potent 5-HT(1A/B/D) receptor antagonists with and without additional SerT activity and a high degree of selectivity over hERG potassium channels. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.Entities:
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Year: 2009 PMID： 19286377 DOI： 10.1016/j.bmcl.2009.02.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823