| Literature DB >> 19286267 |
Saima Humayun1, May Gohar, Kathryn Volkening, Katie Moisse, Cheryl Leystra-Lantz, Jennifer Mepham, Jesse McLean, Michael J Strong.
Abstract
In NFL-/- mice, a model of motor neuron degeneration in ALS, degenerating spinal motor neurons express high levels of the receptor for the C5a anaphylatoxin (C5aR) early in the disease process. C5a is a potent in vitro neurotoxin for both Neuro2A and NGF-differentiated PC12 cells. While no interaction was observed between glutamate and C5a, both C5a and kainate upregulated the expression of activated C5aR. C5aR expression was increased in motor neurons in ALS. This data suggests that the early upregulation of C5aR may contribute to motor neuron damage that potentiates excitotoxicity in ALS.Entities:
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Year: 2009 PMID： 19286267 DOI： 10.1016/j.jneuroim.2009.01.028
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478