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Literature DB >> 19285746

The complex relationship of gene duplication and essentiality.

Takashi Makino¹, Karsten Hokamp, Aoife McLysaght.

Abstract

In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.

Entities: Species

Mesh：

Year: 2009 PMID： 19285746 DOI： 10.1016/j.tig.2009.03.001

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

55 in total

1. Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function.

Authors: James A Cotton; James O McInerney
Journal: Proc Natl Acad Sci U S A Date: 2010-09-17 Impact factor: 11.205

The complex relationship of gene duplication and essentiality.

1. Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function.

2. Ohnologs in the human genome are dosage balanced and frequently associated with disease.

3. Identification and characterization of essential genes in the human genome.

4. Gene Duplicability of Core Genes Is Highly Consistent across All Angiosperms.

5. Ohnologs are overrepresented in pathogenic copy number mutations.

6. Functional compensation by duplicated genes in mouse.

7. Duplicability of self-interacting human genes.

8. Evolutionary persistence of functional compensation by duplicate genes in Arabidopsis.

9. Ordered structure of the transcription network inherited from the yeast whole-genome duplication.

10. Modification of gene duplicability during the evolution of protein interaction network.