| Literature DB >> 19285453 |
Jimmie Colon1, Luis Herrera, Joshua Smith, Swanand Patil, Chris Komanski, Patrick Kupelian, Sudipta Seal, D Wayne Jenkins, Cheryl H Baker.
Abstract
In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO(2)) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO(2) nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO(2) nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy.Entities:
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Year: 2009 PMID： 19285453 DOI： 10.1016/j.nano.2008.10.003
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307