| Literature DB >> 19284796 |
Carlos Fernandes1, Elisabeth Pereira, Sophie Faure, David J Aitken.
Abstract
A short, convenient, gram scale protocol has been established to allow facile access to all four stereoisomers of 2-aminocyclobutanecarboxylic acid, each in enantiomerically pure form (ee >99%). Starting from the readily available cis racemate, the procedure combines efficient alpha-phenylethylamine derivative resolution and controlled cis-to-trans epimerization procedures, and proceeds with invariably high yields.Entities:
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Year: 2009 PMID： 19284796 DOI： 10.1021/jo900175p
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354