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Literature DB >> 19284734

Label-free DNA sensor based on surface charge modulated ionic conductance.

Abstract

The surface charge effect in controlling ionic conductance through a nanoporous alumina membrane is investigated for its application in a convenient detection method of unlabeled DNA. To this goal, surface modification with mixtures of neutral silanes and morpholinos (neutral analogues of DNA) was optimized to yield a strong effect on ionic conductance change upon DNA binding, which can exceed an order of magnitude. The effect can be employed in fabrication of inexpensive DNA sensors.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
DNA
Aluminum Oxide

Year: 2009 PMID： 19284734 PMCID： PMC2729444 DOI： 10.1021/nn900113x

Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881

12 in total

1. Metal Oxide Surfaces and Their Interactions with Aqueous Solutions and Microbial Organisms.

Authors: Gordon E. Brown; Victor E. Henrich; William H. Casey; David L. Clark; Carrick Eggleston; Andrew Felmy; D. Wayne Goodman; Michael Grätzel; Gary Maciel; Maureen I. McCarthy; Kenneth H. Nealson; Dimitri A. Sverjensky; Michael F. Toney; John M. Zachara
Journal: Chem Rev Date: 1999-01-13 Impact factor: 60.622

2. Surface-charge-governed ion transport in nanofluidic channels.

Authors: Derek Stein; Maarten Kruithof; Cees Dekker
Journal: Phys Rev Lett Date: 2004-07-15 Impact factor: 9.161

3. "Direct" detection and separation of DNA using nanoporous alumina filters.

Authors: Ivan Vlassiouk; Alexey Krasnoslobodtsev; Sergei Smirnov; Markus Germann
Journal: Langmuir Date: 2004-11-09 Impact factor: 3.882

4. Sensing DNA hybridization via ionic conductance through a nanoporous electrode.

Authors: Ivan Vlassiouk; Pavel Takmakov; Sergei Smirnov
Journal: Langmuir Date: 2005-05-24 Impact factor: 3.882

5. Hybridization-modulated ion fluxes through peptide-nucleic-acid- functionalized gold nanotubes. A new approach to quantitative label-free DNA analysis.

Authors: Gyula Jágerszki; Róbert E Gyurcsányi; Lajos Höfler; Ernö Pretsch
Journal: Nano Lett Date: 2007-05-08 Impact factor: 11.189

6. Ionic selectivity of single nanochannels.

Authors: Ivan Vlassiouk; Sergei Smirnov; Zuzanna Siwy
Journal: Nano Lett Date: 2008-06-18 Impact factor: 11.189

7. Identification of the cystic fibrosis gene: genetic analysis.

Authors: B Kerem; J M Rommens; J A Buchanan; D Markiewicz; T K Cox; A Chakravarti; M Buchwald; L C Tsui
Journal: Science Date: 1989-09-08 Impact factor: 47.728

8. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.

Authors: J R Riordan; J M Rommens; B Kerem; N Alon; R Rozmahel; Z Grzelczak; J Zielenski; S Lok; N Plavsic; J L Chou
Journal: Science Date: 1989-09-08 Impact factor: 47.728

9. The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.

Authors: Eva Y Chen; M Claire Bartlett; Tip W Loo; David M Clarke
Journal: J Biol Chem Date: 2004-07-21 Impact factor: 5.157

10. Enabling electrical biomolecular detection in high ionic concentrations and enhancement of the detection limit thereof by coupling a nanofluidic crystal with reconfigurable ion concentration polarization.

Authors: Wei Ouyang; Jongyoon Han; Wei Wang
Journal: Lab Chip Date: 2017-11-07 Impact factor: 6.799

Label-free DNA sensor based on surface charge modulated ionic conductance.

1. Metal Oxide Surfaces and Their Interactions with Aqueous Solutions and Microbial Organisms.

2. Surface-charge-governed ion transport in nanofluidic channels.

3. "Direct" detection and separation of DNA using nanoporous alumina filters.

4. Sensing DNA hybridization via ionic conductance through a nanoporous electrode.

5. Hybridization-modulated ion fluxes through peptide-nucleic-acid- functionalized gold nanotubes. A new approach to quantitative label-free DNA analysis.

6. Ionic selectivity of single nanochannels.

7. Identification of the cystic fibrosis gene: genetic analysis.

8. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.

9. The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.

10. Identification of the cystic fibrosis gene: chromosome walking and jumping.

1. Resistive amplitude fingerprints during translocation of linear molecules through charged solid-state nanopores.

2. Review article: Fabrication of nanofluidic devices.

3. Protein sensing by nanofluidic crystal and its signal enhancement.

4. Molecular mechanisms in morpholino-DNA surface hybridization.

5. Simple and Versatile Detection of Viruses Using Anodized Alumina Membranes.

6. An ion-exchange nanomembrane sensor for detection of nucleic acids using a surface charge inversion phenomenon.

7. Kinetic mechanisms in morpholino-DNA surface hybridization.

8. Charge-neutral morpholino microarrays for nucleic acid analysis.

9. Electrochemical Studies of Morpholino-DNA Surface Hybridization.

10. Enabling electrical biomolecular detection in high ionic concentrations and enhancement of the detection limit thereof by coupling a nanofluidic crystal with reconfigurable ion concentration polarization.