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Literature DB >> 19284370

Development of novel drugs targeting inhibitors of apoptosis.

John A Flygare, Domagoj Vucic.

Abstract

Mesh：

Year: 2009 PMID： 19284370 DOI： 10.2217/14796694.5.2.141

Source DB: PubMed Journal: Future Oncol ISSN： 1479-6694 Impact factor: 3.404

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4 in total

1. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Authors: John A Flygare; Maureen Beresini; Nageshwar Budha; Helen Chan; Iris T Chan; Sravanthi Cheeti; Frederick Cohen; Kurt Deshayes; Karl Doerner; S Gail Eckhardt; Linda O Elliott; Bainian Feng; Matthew C Franklin; Stacy Frankovitz Reisner; Lewis Gazzard; Jason Halladay; Sarah G Hymowitz; Hank La; Patricia LoRusso; Brigitte Maurer; Lesley Murray; Emile Plise; Clifford Quan; Jean-Philippe Stephan; Shin G Young; Jeffrey Tom; Vickie Tsui; Joanne Um; Eugene Varfolomeev; Domagoj Vucic; Andrew J Wagner; Heidi J A Wallweber; Lan Wang; Joseph Ware; Zhaoyang Wen; Harvey Wong; Jonathan M Wong; Melisa Wong; Susan Wong; Ron Yu; Kerry Zobel; Wayne J Fairbrother
Journal: J Med Chem Date: 2012-03-28 Impact factor: 7.446

Development of novel drugs targeting inhibitors of apoptosis.

1. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

2. X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.

Review 3. Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer.

4. Masking MALT1: the paracaspase's potential for cancer therapy.