BACKGROUND: To investigate whether human papilloma virus (HPV)-specific immune mechanisms can result in tumor clearance, we have created HPV+ and HPV- tonsil cells that form squamous cancers in immune-competent mice. Here, we determine that an immune-specific response can clear HPV+ tumor cells and the cellular requirements to mediate this tumor clearance. METHODS: Through the benefit of this model, we use in vitro and in vivo methods to better understand how HPV+ cells are rejected. RESULT.: The data show that an in vivo antigen-specific antitumor response is generated to HPV+ transformed cells and that this response requires CD4+ and CD8+ cells to mount this antitumor response. CONCLUSION: The findings from this preclinical model will have implications not only in understanding human disease but also as a valuable model for testing immunotherapeutic strategies for HPV+ head and neck cancer.
BACKGROUND: To investigate whether human papilloma virus (HPV)-specific immune mechanisms can result in tumor clearance, we have created HPV+ and HPV- tonsil cells that form squamous cancers in immune-competent mice. Here, we determine that an immune-specific response can clear HPV+ tumor cells and the cellular requirements to mediate this tumor clearance. METHODS: Through the benefit of this model, we use in vitro and in vivo methods to better understand how HPV+ cells are rejected. RESULT.: The data show that an in vivo antigen-specific antitumor response is generated to HPV+ transformed cells and that this response requires CD4+ and CD8+ cells to mount this antitumor response. CONCLUSION: The findings from this preclinical model will have implications not only in understanding human disease but also as a valuable model for testing immunotherapeutic strategies for HPV+ head and neck cancer.
Authors: Sayuri Miyauchi; P Dominick Sanders; Kripa Guram; Sangwoo S Kim; Francesca Paolini; Aldo Venuti; Ezra E W Cohen; J Silvio Gutkind; Joseph A Califano; Andrew B Sharabi Journal: Cancer Res Date: 2019-12-17 Impact factor: 12.701
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Authors: Kara S Davis; J Kenneth Byrd; Vikas Mehta; Simon I Chiosea; Seungwon Kim; Robert L Ferris; Jonas T Johnson; Umamaheswar Duvvuri Journal: Otolaryngol Head Neck Surg Date: 2014-05-08 Impact factor: 3.497
Authors: Alice L Tang; John H Owen; Samantha J Hauff; Jung Je Park; Silvana Papagerakis; Carol R Bradford; Thomas E Carey; Mark E Prince Journal: Otolaryngol Head Neck Surg Date: 2013-04-12 Impact factor: 3.497
Authors: Kara S Davis; John A Vargo; Robert L Ferris; Steven A Burton; James P Ohr; David A Clump; Dwight E Heron Journal: Oral Oncol Date: 2014-08-28 Impact factor: 5.337