BACKGROUND: The aim of this study was to assess the relationship between the serum ferritin level and the 1-year outcome in diabetic maintenance hemodialysis (MHD) patients. METHODS: The prospective clinical study enrolled 187 diabetic MHD patients from a university hospital in Taiwan. All the patients were divided into 3 groups according to their serum ferritin levels: group I (<200 ng/mL; n = 71), group II (200-700 ng/mL; n = 97), and group III (>700 ng/mL; n = 19). A total of 26 demographic, clinical, and laboratory variables were analyzed as predictors of the 1-year mortality. RESULTS: There were no significant differences between these 3 groups except in their erythropoietin usage, hemoglobin, transferrin saturation, and high-sensitive C-reactive protein levels. The 1-year mortality rates were 9.2%, 11.4%, and 46.2% in groups I, II, and III, respectively. Group I and group II patients had a lower 1-year mortality rate than group III patients (log-rank test; chi = 8.807; P = 0.0112). CONCLUSION: The study suggested that serum ferritin levels predict both all-cause and infection-cause 1-year mortality in diabetic patients on MHD. In such patients, the serum ferritin levels are associated with both iron stores and the inflammation status.
BACKGROUND: The aim of this study was to assess the relationship between the serum ferritin level and the 1-year outcome in diabetic maintenance hemodialysis (MHD) patients. METHODS: The prospective clinical study enrolled 187 diabetic MHDpatients from a university hospital in Taiwan. All the patients were divided into 3 groups according to their serum ferritin levels: group I (<200 ng/mL; n = 71), group II (200-700 ng/mL; n = 97), and group III (>700 ng/mL; n = 19). A total of 26 demographic, clinical, and laboratory variables were analyzed as predictors of the 1-year mortality. RESULTS: There were no significant differences between these 3 groups except in their erythropoietin usage, hemoglobin, transferrin saturation, and high-sensitive C-reactive protein levels. The 1-year mortality rates were 9.2%, 11.4%, and 46.2% in groups I, II, and III, respectively. Group I and group II patients had a lower 1-year mortality rate than group III patients (log-rank test; chi = 8.807; P = 0.0112). CONCLUSION: The study suggested that serum ferritin levels predict both all-cause and infection-cause 1-year mortality in diabeticpatients on MHD. In such patients, the serum ferritin levels are associated with both iron stores and the inflammation status.
Authors: Christina Ellervik; Henrik Ullits Andersen; Anne Tybjærg-Hansen; Merete Frandsen; Henrik Birgens; Børge G Nordestgaard; Thomas Mandrup-Poulsen Journal: Diabetes Care Date: 2013-06-25 Impact factor: 19.112
Authors: Soon Mi Hur; Hye Young Ju; Moo Yong Park; Soo Jeong Choi; Jin Kuk Kim; Seung Duk Hwang Journal: Korean J Intern Med Date: 2014-06-27 Impact factor: 2.884