Literature DB >> 19282670

Chk1 phosphorylation during mitosis: a new role for a master regulator.

Deborah Wilsker1, Fred Bunz.   

Abstract

The human DNA damage responses are modulated by both nonessential and essential pathways. The extensively studied ATM kinase and p53 are examples of the former. While loss-of-function mutations in genes that encode ATM and p53 cause marked predispositions to cancer, the loss of these proteins does not appear to impact basic cell growth and proliferation. In contrast, the checkpoint kinase Chk1 and its upstream activator ATR are essential.(1-4) What do these proteins do in undamaged cells?

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Year:  2009        PMID： 19282670      PMCID： PMC2774453          DOI： 10.4161/cc.8.8.8148

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  23 in total

1.  Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.

Authors:  V Costanzo; K Robertson; C Y Ying; E Kim; E Avvedimento; M Gottesman; D Grieco; J Gautier
Journal:  Mol Cell       Date:  2000-09       Impact factor: 17.970

Review 2.  Cell cycle checkpoint signaling through the ATM and ATR kinases.

Authors:  R T Abraham
Journal:  Genes Dev       Date:  2001-09-01       Impact factor: 11.361

3.  ATR regulates fragile site stability.

Authors:  Anne M Casper; Paul Nghiem; Martin F Arlt; Thomas W Glover
Journal:  Cell       Date:  2002-12-13       Impact factor: 41.582

Review 4.  Checking on the fork: the DNA-replication stress-response pathway.

Authors:  Alexander J Osborn; Stephen J Elledge; Lee Zou
Journal:  Trends Cell Biol       Date:  2002-11       Impact factor: 20.808

5.  ATR and ATRIP: partners in checkpoint signaling.

Authors:  D Cortez; S Guntuku; J Qin; S J Elledge
Journal:  Science       Date:  2001-11-23       Impact factor: 47.728

6.  ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.

Authors:  H Zhao; H Piwnica-Worms
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

7.  Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

Authors:  Q Liu; S Guntuku; X S Cui; S Matsuoka; D Cortez; K Tamai; G Luo; S Carattini-Rivera; F DeMayo; A Bradley; L A Donehower; S J Elledge
Journal:  Genes Dev       Date:  2000-06-15       Impact factor: 11.361

8.  The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways.

Authors:  Jacob Falck; John H J Petrini; Bret R Williams; Jiri Lukas; Jiri Bartek
Journal:  Nat Genet       Date:  2002-02-19       Impact factor: 38.330

9.  ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

Authors:  E J Brown; D Baltimore
Journal:  Genes Dev       Date:  2000-02-15       Impact factor: 11.361

10.  Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control.

Authors:  Deborah Wilsker; Eva Petermann; Thomas Helleday; Fred Bunz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-17       Impact factor: 11.205
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  4 in total

1.  VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.

Authors:  Sandrine Passemard; Vincent El Ghouzzi; Hala Nasser; Catherine Verney; Guilan Vodjdani; Adrien Lacaud; Sophie Lebon; Marc Laburthe; Patrick Robberecht; Jeannette Nardelli; Shyamala Mani; Alain Verloes; Pierre Gressens; Vincent Lelièvre
Journal:  J Clin Invest       Date:  2011-08       Impact factor: 14.808

2.  To go or not to go?

Authors:  Michael Andäng; Petra Sekyrova
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

3.  A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.

Authors:  Stefano Gastaldello; Sebastian Hildebrand; Omid Faridani; Simone Callegari; Mia Palmkvist; Claudia Di Guglielmo; Maria G Masucci
Journal:  Nat Cell Biol       Date:  2010-02-28       Impact factor: 28.824

4.  The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells.

Authors:  S Shirazi Fard; Mke Blixt; F Hallböök
Journal:  Cell Death Discov       Date:  2015-09-07
  4 in total

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