Literature DB >> 19282190

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.

Surya K De1, Li-Hsing Chen, John L Stebbins, Thomas Machleidt, Megan Riel-Mehan, Russell Dahl, Vida Chen, Hongbin Yuan, Elisa Barile, Aras Emdadi, Ria Murphy, Maurizio Pellecchia.   

Abstract

A new series of 2-thioether-benzothiazoles has been synthesized and evaluated for JNK inhibition. The SAR studies led to the discovery of potent, allosteric JNK inhibitors with selectivity against p38.

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Year:  2009        PMID： 19282190      PMCID： PMC2828351          DOI： 10.1016/j.bmc.2009.02.046

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  26 in total

1.  Selective interaction of JNK protein kinase isoforms with transcription factors.

Authors:  S Gupta; T Barrett; A J Whitmarsh; J Cavanagh; H K Sluss; B Dérijard; R J Davis
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

2.  Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase.

Authors:  Thomas Rückle; Marco Biamonte; Tania Grippi-Vallotton; Steve Arkinstall; Yves Cambet; Montserrat Camps; Christian Chabert; Dennis J Church; Serge Halazy; Xuliang Jiang; Isabelle Martinou; Anthony Nichols; Wolfgang Sauer; Jean-Pierre Gotteland
Journal:  J Med Chem       Date:  2004-12-30       Impact factor: 7.446

3.  Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

Authors:  S H Yang; A J Whitmarsh; R J Davis; A D Sharrocks
Journal:  EMBO J       Date:  1998-03-16       Impact factor: 11.598

4.  Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

Authors:  M D Eldridge; C W Murray; T R Auton; G V Paolini; R P Mee
Journal:  J Comput Aided Mol Des       Date:  1997-09       Impact factor: 3.686

5.  c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.

Authors:  T Kallunki; T Deng; M Hibi; M Karin
Journal:  Cell       Date:  1996-11-29       Impact factor: 41.582

6.  Development and validation of a genetic algorithm for flexible docking.

Authors:  G Jones; P Willett; R C Glen; A R Leach; R Taylor
Journal:  J Mol Biol       Date:  1997-04-04       Impact factor: 5.469

7.  Texture mapping: a new tool for molecular graphics.

Authors:  M Teschner; C Henn; H Vollhardt; S Reiling; J Brickmann
Journal:  J Mol Graph       Date:  1994-06

8.  A cytoplasmic inhibitor of the JNK signal transduction pathway.

Authors:  M Dickens; J S Rogers; J Cavanagh; A Raitano; Z Xia; J R Halpern; M E Greenberg; C L Sawyers; R J Davis
Journal:  Science       Date:  1997-08-01       Impact factor: 47.728

9.  Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.

Authors:  Hideaki Kaneto; Yoshihisa Nakatani; Takeshi Miyatsuka; Dan Kawamori; Taka-aki Matsuoka; Munehide Matsuhisa; Yoshitaka Kajimoto; Hidenori Ichijo; Yoshimitsu Yamasaki; Masatsugu Hori
Journal:  Nat Med       Date:  2004-09-26       Impact factor: 53.440

10.  Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

Authors:  Yong-Seok Heo; Su-Kyoung Kim; Chang Il Seo; Young Kwan Kim; Byung-Je Sung; Hye Shin Lee; Jae Il Lee; Sam-Yong Park; Jin Hwan Kim; Kwang Yeon Hwang; Young-Lan Hyun; Young Ho Jeon; Seonggu Ro; Joong Myung Cho; Tae Gyu Lee; Chul-Hak Yang
Journal:  EMBO J       Date:  2004-05-13       Impact factor: 11.598
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  7 in total

Review 1.  Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinases.

Authors:  Michael J Schnieders; Tamer S Kaoud; Chunli Yan; Kevin N Dalby; Pengyu Ren
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

2.  Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor.

Authors:  John L Stebbins; Surya K De; Petra Pavlickova; Vida Chen; Thomas Machleidt; Li-Hsing Chen; Christian Kuntzen; Shinichi Kitada; Michael Karin; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2011-08-23       Impact factor: 7.446

3.  High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.

Authors:  Robert C Reynolds; Subramaniam Ananthan; Ellen Faaleolea; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Melinda I Sosa; Elizabeth Thammasuvimol; E Lucile White; Wei Zhang; John A Secrist
Journal:  Tuberculosis (Edinb)       Date:  2011-06-25       Impact factor: 3.131

4.  Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats.

Authors:  Jeremy W Chambers; Alok Pachori; Shannon Howard; Sarah Iqbal; Philip V LoGrasso
Journal:  J Biol Chem       Date:  2012-12-20       Impact factor: 5.157

5.  From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.

Authors:  Tamer S Kaoud; Chunli Yan; Shreya Mitra; Chun-Chia Tseng; Jiney Jose; Juliana M Taliaferro; Maidina Tuohetahuntila; Ashwini Devkota; Rachel Sammons; Jihyun Park; Heekwang Park; Yue Shi; Jiyong Hong; Pengyu Ren; Kevin N Dalby
Journal:  ACS Med Chem Lett       Date:  2012-08-06       Impact factor: 4.345

Review 6.  A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors.

Authors:  Wenjing Liu; Min He; Yongjun Li; Zhiyun Peng; Guangcheng Wang
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

7.  Biological activities of 2-mercaptobenzothiazole derivatives: a review.

Authors:  Mohammed Afzal Azam; Bhojraj Suresh
Journal:  Sci Pharm       Date:  2012-06-18
  7 in total

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