| Literature DB >> 19282187 |
Ana Carolina C Asbahr1, Luzia Franco, Andersson Barison, Caroline W P Silva, Humberto G Ferraz, Letícia N C Rodrigues.
Abstract
The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.Entities:
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Year: 2009 PMID： 19282187 DOI： 10.1016/j.bmc.2009.02.044
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641