Literature DB >> 19279398

Autophagy genes mediate the effect of calcineurin on life span in C. elegans.

Meenakshi Dwivedi1, Hyun-Ok Song, Joohong Ahnn.   

Abstract

Calcineurin (CaN) is a serine/threonine phosphatase, activated by Ca2+/calmodulin (Ca2+/CaM). CaN is known to regulate various cellular responses in different organisms. A recent study showed an extended life span in the calcineurin mutants of C. elegans. In this study, we report that calcineurin defective strains exhibit enhanced autophagy. In addition, we found two essential autophagy genes (bec-1 and atg-7) are required for the life-span extension in calcineurin null mutants [cnb-1(jh103)]. Thus, for the first time we suggest that autophagy genes are required for the life-span regulation in calcineurin defective C. elegans strains.

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Year:  2009        PMID： 19279398     DOI： 10.4161/auto.5.5.8157

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  25 in total

1.  Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.

Authors:  Kristopher Burkewitz; Ianessa Morantte; Heather J M Weir; Robin Yeo; Yue Zhang; Frank K Huynh; Olga R Ilkayeva; Matthew D Hirschey; Ana R Grant; William B Mair
Journal:  Cell       Date:  2015-02-26       Impact factor: 41.582

2.  Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae.

Authors:  Sean Connolly; Devona Quasi-Woode; Laura Waldron; Christian Eberly; Kerri Waters; Eric M Muller; Tami J Kingsbury
Journal:  Genetics       Date:  2018-05-07       Impact factor: 4.562

Review 3.  Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis.

Authors:  Chanhee Kang; Leon Avery
Journal:  FEBS J       Date:  2009-10-30       Impact factor: 5.542

4.  ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.

Authors:  Huiwen Song; Jun Pu; Lin Wang; Lihua Wu; Jianmin Xiao; Qigong Liu; Jun Chen; Min Zhang; Yang Liu; Mingke Ni; Jinggang Mo; Yunliang Zheng; Deli Wan; XiongJiu Cai; Yaping Cao; Weiyi Xiao; Lei Ye; Enyuan Tu; Zhihai Lin; Jianxin Wen; Xiaoling Lu; Jian He; Yi Peng; Jing Su; Heng Zhang; Yongxiang Zhao; Meihua Lin; Zhiyong Zhang
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

Review 5.  Essential role for autophagy in life span extension.

Authors:  Frank Madeo; Andreas Zimmermann; Maria Chiara Maiuri; Guido Kroemer
Journal:  J Clin Invest       Date:  2015-01-02       Impact factor: 14.808

6.  Disruption of endocytic pathway regulatory genes activates autophagy in C. elegans.

Authors:  Meenakshi Dwivedi; Hyun Sung; Haihong Shen; Byung-Jae Park; Sangho Lee
Journal:  Mol Cells       Date:  2011-05-19       Impact factor: 5.034

7.  Implication of Ca2+ in the regulation of replicative life span of budding yeast.

Authors:  Ryohei Tsubakiyama; Masaki Mizunuma; Anri Gengyo; Josuke Yamamoto; Kazunori Kume; Tokichi Miyakawa; Dai Hirata
Journal:  J Biol Chem       Date:  2011-06-28       Impact factor: 5.157

8.  ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans.

Authors:  Meenakshi Sharma; Renu Pandey; Daman Saluja
Journal:  Autophagy       Date:  2018-07-20       Impact factor: 16.016

Review 9.  Impact papers on aging in 2009.

Authors:  Mikhail V Blagosklonny; Judy Campisi; David A Sinclair; Andrzej Bartke; Maria A Blasco; William M Bonner; Vilhelm A Bohr; Robert M Brosh; Anne Brunet; Ronald A Depinho; Lawrence A Donehower; Caleb E Finch; Toren Finkel; Myriam Gorospe; Andrei V Gudkov; Michael N Hall; Siegfried Hekimi; Stephen L Helfand; Jan Karlseder; Cynthia Kenyon; Guido Kroemer; Valter Longo; Andre Nussenzweig; Heinz D Osiewacz; Daniel S Peeper; Thomas A Rando; K Lenhard Rudolph; Paolo Sassone-Corsi; Manuel Serrano; Norman E Sharpless; Vladimir P Skulachev; Jonathan L Tilly; John Tower; Eric Verdin; Jan Vijg
Journal:  Aging (Albany NY)       Date:  2010-03-23       Impact factor: 5.682

Review 10.  AMPK at the nexus of energetics and aging.

Authors:  Kristopher Burkewitz; Yue Zhang; William B Mair
Journal:  Cell Metab       Date:  2014-04-10       Impact factor: 27.287
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