BACKGROUND: The aim of the study was to determine the influence of fractionated plasma separation and absorption (FPSA) on intracranial pressure (ICP) in acute liver failure (ALF). METHODS: A surgical model of ALF in pigs (35-40 kg) was used. We compared laboratory data and haemodynamic parameters from the ALF control group to the ALF group treated by Prometheus using ANOVA with repeated measures and grouping factors, by calculating the area under the curve, and by the Mann-Whitney rank test. RESULTS: Bilirubin levels differed significantly in favour of the FPSA treatment group: after 6 h 12.81 +/- 6.54 versus 29.84 +/- 9.99, after 9 h 11.94 +/- 4.14 versus 29.95 +/- 12.36 (p < 0.01) and after 12 h 13.88 +/- 6.31 versus 26.10 +/- 12.23 mmol/l (p < 0.05). ICP values differed significantly in favour of the FPSA treatment group: after 9 h 19.1 +/- 4.09 versus 24.1 +/- 2.85 (p < 0.01), after 10 h 21.9 +/- 3.63 versus 25.1 +/- 2.19, after 11 h 22.5 +/- 3.98 versus 26.3 +/- 3.50, and after 12 h 24.0 +/- 4.66 versus 29.8 +/- 5.88 mm Hg (p < 0.05). CONCLUSION: The authors demonstrated that a significant decrease in ICP was found in pigs with ALF following treatment by FPSA. Copyright 2009 S. Karger AG, Basel.
BACKGROUND: The aim of the study was to determine the influence of fractionated plasma separation and absorption (FPSA) on intracranial pressure (ICP) in acute liver failure (ALF). METHODS: A surgical model of ALF in pigs (35-40 kg) was used. We compared laboratory data and haemodynamic parameters from the ALF control group to the ALF group treated by Prometheus using ANOVA with repeated measures and grouping factors, by calculating the area under the curve, and by the Mann-Whitney rank test. RESULTS:Bilirubin levels differed significantly in favour of the FPSA treatment group: after 6 h 12.81 +/- 6.54 versus 29.84 +/- 9.99, after 9 h 11.94 +/- 4.14 versus 29.95 +/- 12.36 (p < 0.01) and after 12 h 13.88 +/- 6.31 versus 26.10 +/- 12.23 mmol/l (p < 0.05). ICP values differed significantly in favour of the FPSA treatment group: after 9 h 19.1 +/- 4.09 versus 24.1 +/- 2.85 (p < 0.01), after 10 h 21.9 +/- 3.63 versus 25.1 +/- 2.19, after 11 h 22.5 +/- 3.98 versus 26.3 +/- 3.50, and after 12 h 24.0 +/- 4.66 versus 29.8 +/- 5.88 mm Hg (p < 0.05). CONCLUSION: The authors demonstrated that a significant decrease in ICP was found in pigs with ALF following treatment by FPSA. Copyright 2009 S. Karger AG, Basel.
Authors: Karolin Thiel; Martin Schenk; Alexander Etspüler; Thomas Schenk; Matthias H Morgalla; Alfred Königsrainer; Christian Thiel Journal: BMC Gastroenterol Date: 2011-07-14 Impact factor: 3.067
Authors: Ahmed Al-Chalabi; Edouard Matevossian; Anne-K V Thaden; Peter Luppa; Albrecht Neiss; Tibor Schuster; Zejian Yang; Catherine Schreiber; Patrick Schimmel; Ewald Nairz; Aurel Perren; Peter Radermacher; Wolfgang Huber; Roland M Schmid; Bernhard Kreymann Journal: BMC Gastroenterol Date: 2013-05-13 Impact factor: 3.067
Authors: Josef Prazak; Eva Laszikova; Tomas Pantoflicek; Ondrej Ryska; Eva Koblihova; Miroslav Ryska Journal: BMC Gastroenterol Date: 2013-06-08 Impact factor: 3.067