Literature DB >> 19279

The effect of ion pair formation on the antimuscarinic activity of methantheline.

M N Gillespie, L Diamond, J Newburger, H B Kostenbauder.   

Abstract

The quaternary ammonium compound, methantheline, was found to antagonize acetylcholine induced contractions in isolated guinea pig ileum by a mechanism which did not conform to the criteria for either competitive or non-competitive inhibition. Enhancement of the lipid solubility of methantheline by formation of an ion pair with trichloracetate failed to influence its cholinergic inhibitory activity. The results suggest that in the guinea pig ileum a) an intracellular site of action does not exist for methantheline and b) the membrane receptors for methantheline most likely are located in an aqueous environment.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 19279     DOI： 10.1007/BF01951292

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  PHOTOMETRIC DETERMINATION OF AMINES AND QUATERNARY AMMONUIM COMPOUNDS WITH BROMOTHYMOL BLUE.

Authors:  G SCHILL
Journal:  Acta Pharm Suec       Date:  1965-04

2.  Interactions between local anesthetics and spasmogens on the guinea-pig ileum.

Authors:  R W Bury; M L Mashford
Journal:  J Pharmacol Exp Ther       Date:  1976-06       Impact factor: 4.030

3.  Antagonism at the cholinergic receptor of denervated diaphragm by monoquaternary and bisquaternary nitrogen compounds.

Authors:  S E Freeman; R J Turner
Journal:  Aust J Exp Biol Med Sci       Date:  1973-04

4.  Application of ion-pair methods to drug extraction from biological fluids. I. Quantitative determination of biguanides in urine.

Authors:  E R Garrett; J Tsau
Journal:  J Pharm Sci       Date:  1972-09       Impact factor: 3.534

5.  Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates.

Authors:  J T Doluisio; N F Billups; L W Dittert; E T Sugita; J V Swintosky
Journal:  J Pharm Sci       Date:  1969-10       Impact factor: 3.534

6.  Ion-pair extraction of pharmaceutical amines. IV. Influence of anion on enthalpic, entropic, and free energy changes resulting from phase transfer.

Authors:  A F Michaelis; T Higuchi
Journal:  J Pharm Sci       Date:  1969-02       Impact factor: 3.534

7.  Action of local anesthetics on coupling systems in muscle.

Authors:  C P Bianchi; T C Bolton
Journal:  J Pharmacol Exp Ther       Date:  1967-08       Impact factor: 4.030
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.