Literature DB >> 1927837

Abuse of skeletal muscle relaxants.

N C Elder1.   

Abstract

Centrally acting skeletal muscle relaxants are potential drugs of abuse. Although skeletal muscle relaxants are occasionally the primary drug of abuse, they are often used along with other central nervous system depressants, such as narcotics or alcohol. The major toxic effects are respiratory depression and coma. For the most part, the abuse problem is initiated and sustained iatrogenically. Physicians should be aware of the abuse potential of skeletal muscle relaxants.

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Year:  1991        PMID: 1927837

Source DB:  PubMed          Journal:  Am Fam Physician        ISSN: 0002-838X            Impact factor:   3.292


  7 in total

1.  Assessment of direct gating and allosteric modulatory effects of meprobamate in recombinant GABA(A) receptors.

Authors:  Manish Kumar; Glenn H Dillon
Journal:  Eur J Pharmacol       Date:  2016-02-09       Impact factor: 4.432

2.  Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry.

Authors:  Barbara Melilli; Cateno Piazza; Daniela Cristina Vitale; Maria Rosa Marano; Andrea Pecori; Paolo Mattana; Valentina Li Volsi; Carmelo Iuculano; Francesco Cardì; Filippo Drago
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2011-03-30       Impact factor: 2.441

3.  Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA(A) receptors.

Authors:  Manoj Kumar; Lorie A González; Glenn H Dillon
Journal:  Neuropharmacology       Date:  2015-04-18       Impact factor: 5.250

4.  The CYP2C19 genotype and the use of oral contraceptives influence the pharmacokinetics of carisoprodol in healthy human subjects.

Authors:  Jørgen G Bramness; Svetlana Skurtveit; Margaretha Gulliksen; Harald Breilid; Vidar M Steen; Jørg Mørland
Journal:  Eur J Clin Pharmacol       Date:  2005-07-15       Impact factor: 2.953

5.  Abuse Potential of Soma: the GABA(A) Receptor as a Target.

Authors:  Lorie A Gonzalez; Michael B Gatch; Michael J Forster; Glenn H Dillon
Journal:  Mol Cell Pharmacol       Date:  2009-01-01

6.  Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies.

Authors:  Lorie A Gonzalez; Michael B Gatch; Cynthia M Taylor; Cathy L Bell-Horner; Michael J Forster; Glenn H Dillon
Journal:  J Pharmacol Exp Ther       Date:  2009-02-24       Impact factor: 4.030

Review 7.  Muscle relaxants for non-specific low back pain.

Authors:  M W van Tulder; T Touray; A D Furlan; S Solway; L M Bouter
Journal:  Cochrane Database Syst Rev       Date:  2003
  7 in total

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