Literature DB >> 19278338

Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential.

Natasha Schneider1, Uma Krishna, Judith Romero-Gallo, Dawn A Israel, M Blanca Piazuelo, M Constanza Camargo, Liviu A Sicinschi, Barbara G Schneider, Pelayo Correa, Richard M Peek.   

Abstract

Helicobacter pylori cagA-positive strains exert population-specific risks for gastric cancer. We determined whether variations in CagA phosphorylation motifs were associated with carcinogenic or proinflammatory epithelial phenotypes induced by strains from regions with divergent cancer risks (Colombia and Nashville, TN). Motif number was significantly related to levels of CagA phosphorylation and cytoskeletal abnormalities. Precancerous isolates possessed a higher number of motifs, and precancerous strains from Nashville induced higher levels of IL-8 than Colombian strains. These results indicate that CagA variants are linked with premalignant lesions in distinct populations and that epithelial responses to these strains are selective based upon locale.

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Year:  2009        PMID： 19278338      PMCID： PMC2828761          DOI： 10.1086/597416

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion.

Authors:  Richard H Argent; James L Hale; Emad M El-Omar; John C Atherton
Journal:  J Med Microbiol       Date:  2008-09       Impact factor: 2.472

2.  Consensus and variable region PCR analysis of Helicobacter pylori 3' region of cagA gene in isolates from individuals with or without peptic ulcer.

Authors:  C A Rota; J C Pereira-Lima; C Blaya; N B Nardi
Journal:  J Clin Microbiol       Date:  2001-02       Impact factor: 5.948

Review 3.  Helicobacter pylori and gastrointestinal tract adenocarcinomas.

Authors:  Richard M Peek; Martin J Blaser
Journal:  Nat Rev Cancer       Date:  2002-01       Impact factor: 60.716

4.  Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle.

Authors:  R M Peek; M J Blaser; D J Mays; M H Forsyth; T L Cover; S Y Song; U Krishna; J A Pietenpol
Journal:  Cancer Res       Date:  1999-12-15       Impact factor: 12.701

5.  Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma?

Authors:  Luis E Bravo; Leen-Jan van Doom; J Luis Realpe; Pelayo Correa
Journal:  Am J Gastroenterol       Date:  2002-11       Impact factor: 10.864

6.  Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH.

Authors:  Y Yamaoka; H M El-Zimaity; O Gutierrez; N Figura; J G Kim; T Kodama; K Kashima; D Y Graham; J K Kim
Journal:  Gastroenterology       Date:  1999-08       Impact factor: 22.682

7.  Activation of beta-catenin by carcinogenic Helicobacter pylori.

Authors:  Aime T Franco; Dawn A Israel; Mary K Washington; Uma Krishna; James G Fox; Arlin B Rogers; Andrew S Neish; Lauren Collier-Hyams; Guillermo I Perez-Perez; Masanori Hatakeyama; Robert Whitehead; Kristin Gaus; Daniel P O'Brien; Judith Romero-Gallo; Richard M Peek
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-18       Impact factor: 11.205

Review 8.  Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994.

Authors:  M F Dixon; R M Genta; J H Yardley; P Correa
Journal:  Am J Surg Pathol       Date:  1996-10       Impact factor: 6.394

9.  Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan.

Authors:  Takeshi Azuma; Akiyo Yamakawa; Shiho Yamazaki; Kanako Fukuta; Masahiro Ohtani; Yoshiyuki Ito; Manabu Dojo; Yukinao Yamazaki; Masaru Kuriyama
Journal:  J Infect Dis       Date:  2002-11-11       Impact factor: 5.226

10.  Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

Authors:  Hideaki Higashi; Ryouhei Tsutsumi; Akiko Fujita; Shiho Yamazaki; Masahiro Asaka; Takeshi Azuma; Masanori Hatakeyama
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205
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  7 in total

1.  Surreptitious manipulation of the human host by Helicobacter pylori.

Authors:  Dawn A Israel; Richard M Peek
Journal:  Gut Microbes       Date:  2010-03

Review 2.  The Helicobacter pylori cag Pathogenicity Island.

Authors:  Jennifer M Noto; Richard M Peek
Journal:  Methods Mol Biol       Date:  2012

Review 3.  Role of innate immunity in Helicobacter pylori-induced gastric malignancy.

Authors:  Richard M Peek; Chris Fiske; Keith T Wilson
Journal:  Physiol Rev       Date:  2010-07       Impact factor: 37.312

4.  CagA EPIYA polymorphisms in Colombian Helicobacter pylori strains and their influence on disease-associated cellular responses.

Authors:  Carlos Alberto Fajardo; Andrés Javier Quiroga; Andrea Coronado; Karen Labrador; Nicole Acosta; Pilar Delgado; Carlos Jaramillo; María Mercedes Bravo
Journal:  World J Gastrointest Oncol       Date:  2013-03-15

5.  A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions.

Authors:  Xue-Song Zhang; Nicole Tegtmeyer; Leah Traube; Shawn Jindal; Guillermo Perez-Perez; Heinrich Sticht; Steffen Backert; Martin J Blaser
Journal:  PLoS Pathog       Date:  2015-02-03       Impact factor: 6.823

Review 6.  Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis.

Authors:  Qiuping Li; Jingwei Liu; Yuehua Gong; Yuan Yuan
Journal:  Medicine (Baltimore)       Date:  2017-04       Impact factor: 1.889

7.  cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection.

Authors:  Eliana Rocío Rodríguez Gómez; William Otero Regino; Pedro A Monterrey; Alba Alicia Trespalacios Rangel
Journal:  PLoS One       Date:  2020-01-10       Impact factor: 3.240
  7 in total

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