| Literature DB >> 19277371 |
Feng Zheng1, Xingang Zhang, Feng-Ling Qing.
Abstract
A new approach for the stereoselective synthesis of 2',3'-dideoxy-6',6'-difluoro-2'-thionucleosides, analogues of highly bioactive L-OddC and 3TC, has been developed via TMSCl/pyridine induced stereoselective Reformatskii-Claisen rearrangement of secondary allyl chlorodifluoroacetate and then a regioselective Pummerer reaction to introduce bases.Entities:
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Year: 2009 PMID： 19277371 DOI： 10.1039/b819289h
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222