Literature DB >> 19276971

Evidence for transformation of fibroadenoma of the breast to malignant phyllodes tumor.

Kurt B Hodges1, Fadi W Abdul-Karim, Mingsheng Wang, Antonio Lopez-Beltran, Rodolfo Montironi, Samantha Easley, Shaobo Zhang, Nancy Wang, Gregory T MacLennan, Liang Cheng.   

Abstract

Fibroadenoma (FA) and phyllodes tumor (PT) of the breast are biphasic tumors composed of variable proportions of epithelial and stromal cells. We identified a case of synchronous FA and PT in the same breast mass. Using laser capture microdissection, loss of heterozygosity analysis was performed on these components to gain potential insight into the histogenetic relationship between FA and PT. Genomic DNA was analyzed at 10 microsatellite loci by polymerase chain reaction. Both tumors showed allelic loss at D7S522. In addition, phylloid tumor showed allelic loss at TP53 and D22S264, not observed in FA. Our data suggest that FA and PT are clonally related and allelic loss at TP53 and D22S264 may be implicated in the progression of FA to phyllode tumor.

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Year:  2009        PMID： 19276971     DOI： 10.1097/PAI.0b013e318194d992

Source DB:  PubMed          Journal:  Appl Immunohistochem Mol Morphol        ISSN： 1533-4058


  10 in total

1.  Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study.

Authors:  Benjamin Yongcheng Tan; Nur Diyana Md Nasir; Huan Ying Chang; Cedric Chuan Young Ng; Peiyong Guan; Sanjanaa Nagarajan; Vikneswari Rajasegaran; Jing Yi Lee; Jing Quan Lim; Aye Aye Thike; Bin Tean Teh; Puay Hoon Tan
Journal:  Mod Pathol       Date:  2020-04-22       Impact factor: 7.842

2.  Genomic landscapes of breast fibroepithelial tumors.

Authors:  Jing Tan; Choon Kiat Ong; Weng Khong Lim; Cedric Chuan Young Ng; Aye Aye Thike; Ley Moy Ng; Vikneswari Rajasegaran; Swe Swe Myint; Sanjanaa Nagarajan; Saranya Thangaraju; Sucharita Dey; Nur Diyana Md Nasir; Giovani Claresta Wijaya; Jing Quan Lim; Dachuan Huang; Zhimei Li; Bernice Huimin Wong; Jason Yong Sheng Chan; John R McPherson; Ioana Cutcutache; Gregory Poore; Su Ting Tay; Wai Jin Tan; Thomas Choudary Putti; Buhari Shaik Ahmad; Philip Iau; Ching Wan Chan; Anthony P H Tang; Wei Sean Yong; Preetha Madhukumar; Gay Hui Ho; Veronique Kiak Mien Tan; Chow Yin Wong; Mikael Hartman; Kong Wee Ong; Benita K T Tan; Steven G Rozen; Patrick Tan; Puay Hoon Tan; Bin Tean Teh
Journal:  Nat Genet       Date:  2015-10-05       Impact factor: 38.330

3.  A TP53 founder mutation, p.R337H, is associated with phyllodes breast tumors in Brazil.

Authors:  Juliana Giacomazzi; Patricia Koehler-Santos; Edenir Inez Palmero; Marcia S Graudenz; Luis Fernando Rivero; Eduardo Lima; Antonio Carlos Kruel Pütten; Pierre Hainaut; Suzi Alves Camey; Rodrigo Depieri Michelli; Cristovam Scapulatempo Neto; Mariana Fitarelli-Kiehl; Geraldo Geyer; Luise Meurer; Ana Geiger; Monica Blaya Azevedo; Vinicius Duval da Silva; Patricia Ashton-Prolla
Journal:  Virchows Arch       Date:  2013-06-21       Impact factor: 4.064

4.  Value of Histogram of Gray-Scale Ultrasound Image in Differential Diagnosis of Small Triple Negative Breast Invasive Ductal Carcinoma and Fibroadenoma.

Authors:  Maolin Xu; Fang Li; Shaonan Yu; Shue Zeng; Gaolong Weng; Peihong Teng; Huimin Yang; Xuefeng Li; Guifeng Liu
Journal:  Cancer Manag Res       Date:  2022-04-21       Impact factor: 3.602

5.  A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway.

Authors:  Ashley Cimino-Mathews; Jessica L Hicks; Rajni Sharma; Russell Vang; Peter B Illei; Angelo De Marzo; Leisha A Emens; Pedram Argani
Journal:  Hum Pathol       Date:  2013-07-31       Impact factor: 3.466

Review 6.  Phyllodes tumours of the breast: a consensus review.

Authors:  Benjamin Y Tan; Geza Acs; Sophia K Apple; Sunil Badve; Ira J Bleiweiss; Edi Brogi; José P Calvo; David J Dabbs; Ian O Ellis; Vincenzo Eusebi; Gelareh Farshid; Stephen B Fox; Shu Ichihara; Sunil R Lakhani; Emad A Rakha; Jorge S Reis-Filho; Andrea L Richardson; Aysegul Sahin; Fernando C Schmitt; Stuart J Schnitt; Kalliopi P Siziopikou; Fernando A Soares; Gary M Tse; Anne Vincent-Salomon; Puay Hoon Tan
Journal:  Histopathology       Date:  2016-01       Impact factor: 5.087

7.  Frequent MED12 mutations in phyllodes tumours of the breast.

Authors:  M Yoshida; S Sekine; R Ogawa; H Yoshida; A Maeshima; Y Kanai; T Kinoshita; A Ochiai
Journal:  Br J Cancer       Date:  2015-04-02       Impact factor: 7.640

8.  Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways.

Authors:  Fresia Pareja; Felipe C Geyer; Rahul Kumar; Pier Selenica; Salvatore Piscuoglio; Charlotte K Y Ng; Kathleen A Burke; Marcia Edelweiss; Melissa P Murray; Edi Brogi; Britta Weigelt; Jorge S Reis-Filho
Journal:  NPJ Breast Cancer       Date:  2017-10-12

9.  Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review.

Authors:  Yining Wang; Yonglin Zhang; Guanglei Chen; Fangming Liu; Chao Liu; Tiantian Xu; Zhenhai Ma
Journal:  Onco Targets Ther       Date:  2018-11-02       Impact factor: 4.147

10.  Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor.

Authors:  Salvatore Piscuoglio; Felipe C Geyer; Kathleen A Burke; Melissa P Murray; Charlotte Ky Ng; Alba Mota; Caterina Marchio; Samuel H Berman; Larry Norton; Edi Brogi; Britta Weigelt; Jorge S Reis-Filho
Journal:  NPJ Breast Cancer       Date:  2016-11-16
  10 in total

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