Breast endocrine cancer.

Mammary carcinoid is an uncommon neoplasm. It is not clear whether mammary carcinoid is a distinct clinical entity or a variant of conventional breast carcinoma. It is well-known that neuroendocrine elements can be demonstrated in ductal and lobular carcinoma. In the study a rare case of neuroendocrine breast tumor is reported. The patient is a 45-year-old woman with a history of a mass feeling in her left breast. Breast sonography identified 3 cm solid nodule with irregular margins. To verify the parameter set of the endocrine cells electron microscopical and histochemical staining were used. Invasive lobular carcinoma was diagnosed by means of microscopic evaluation of a biopsy specimen. Most of the areas studied on the tissue section showed neuroendocrine differentiation. Examination did not reveal any pathological findings in other organs. Neuroendocrine carcinoma of the breast exhibited morphological features similar to those of other etiology. Method of immune histochemical staining the cancer tissue is recommended for diagnostics of the breast cancer. Diagnosis cannot be established based on mammographic or sonographic appearance of these tumors.