| Literature DB >> 19275726 |
M S Parker1, R Sah, E A Park, T Sweatman, A Balasubramaniam, F R Sallee, S L Parker.
Abstract
The heptahelical G protein coupling receptors oligomerize extensively via transmembrane domains, in association with heterotrimeric G proteins. This provides higher affinity for agonists, conformational stability necessary for signal transduction, and protection from intracellular proteinases. The oligomerization is relevant to organismic pathophysiology and could be targeted by natural or modified agonists.Mesh：
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Year: 2009 PMID： 19275726 DOI： 10.2174/1389557510909030329
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862